Department of Medicine, Seoul National University College of Medicine, Seoul, South Korea.
Department of Preventive Medicine, Seoul National University College of Medicine, 103 Daehakno, Jongro-Gu, Seoul, 110-799, South Korea.
AIDS Behav. 2018 Dec;22(12):3971-3980. doi: 10.1007/s10461-018-2232-0.
We investigated whether mortality risk increases with the number of full-term pregnancies in HIV-infected women. Our study is based on data from the ACDIS cohort, collected in rural KwaZulu-Natal, South Africa. Mortality risk for different number of pregnancies in HIV-infected women was analyzed using Cox proportional hazards model. The risk of TB or AIDS mortality in HIV-uninfected women did not change with the number of full-term pregnancies, while the corresponding risk increased markedly in HIV-infected women. The risk of TB or AIDS mortality increased 1.48-fold (95% CI 1.25-1.75), 1.76-fold (95% CI 1.45-2.13), and 1.59-fold (95% CI 1.31-1.94) for one, two, and three or more full-term pregnancies compared to none, respectively. Finally, women who are young (age < 26) have greater risk of TB or AIDS mortality compared to women who are old (age ≥ 26), and women residing in rural areas have greater risk compared to women who reside in non-rural areas.
我们研究了 HIV 感染者的足月妊娠次数与死亡率风险之间的关系。本研究基于南非夸祖鲁-纳塔尔省农村地区 ACDIS 队列的数据。采用 Cox 比例风险模型分析了 HIV 感染者不同妊娠次数的死亡率风险。HIV 未感染者的 TB 或 AIDS 死亡率与足月妊娠次数无关，而 HIV 感染者的相应风险显著增加。与无足月妊娠相比，一次、两次和三次或更多次足月妊娠的 TB 或 AIDS 死亡率风险分别增加了 1.48 倍（95%CI 1.25-1.75）、1.76 倍（95%CI 1.45-2.13）和 1.59 倍（95%CI 1.31-1.94）。最后，与年龄较大（≥26 岁）的女性相比，年龄较小（<26 岁）的女性发生 TB 或 AIDS 死亡的风险更高，与居住在非农村地区的女性相比，居住在农村地区的女性发生 TB 或 AIDS 死亡的风险更高。
