Molecular Biology Program, Sloan Kettering Institute, Memorial Sloan Kettering Cancer Center, New York, NY 10065, USA.
Mol Cell. 2018 Aug 2;71(3):409-418. doi: 10.1016/j.molcel.2018.07.027.
Since the discovery of SUMO twenty years ago, SUMO conjugation has become a widely recognized post-translational modification that targets a myriad of proteins in many processes. Great progress has been made in understanding the SUMO pathway enzymes, substrate sumoylation, and the interplay between sumoylation and other regulatory mechanisms in a variety of contexts. As these research directions continue to generate insights into SUMO-based regulation, several mechanisms by which sumoylation and desumoylation can orchestrate large biological effects are emerging. These include the ability to target multiple proteins within the same cellular structure or process, respond dynamically to external and internal stimuli, and modulate signaling pathways involving other post-translational modifications. Focusing on nuclear function and intracellular signaling, this review highlights a broad spectrum of historical data and recent advances with the aim of providing an overview of mechanisms underlying SUMO-mediated global effects to stimulate further inquiry into intriguing roles of SUMO.
自 20 年前 SUMO 被发现以来，SUMO 缀合已成为一种广泛认可的翻译后修饰，靶向许多过程中的无数蛋白质。在理解 SUMO 途径酶、底物 SUMO 化以及 SUMO 化与其他调节机制在各种情况下的相互作用方面取得了巨大进展。随着这些研究方向继续深入了解基于 SUMO 的调节，SUMO 化和去 SUMO 化可以协调大量生物学效应的几种机制正在出现。这些机制包括能够靶向同一细胞结构或过程中的多个蛋白质，对外部和内部刺激做出动态响应，以及调节涉及其他翻译后修饰的信号通路。本文聚焦于核功能和细胞内信号转导，重点介绍了广泛的历史数据和最新进展，旨在概述 SUMO 介导的全局效应的机制，以激发对 SUMO 有趣作用的进一步探究。
