Guo Linghong, Xiang Weiyi, Pan Zhaoping, Gu He, Jiang Xian
Department of Dermatology, West China Hospital, Sichuan University, Chengdu 610041, China.
Laboratory of Dermatology, Clinical Institute of Inflammation and Immunology (CIII), Frontiers Science Center for Disease-related Molecular Network, West China Hospital, Sichuan University, Chengdu 610041, China.
Acta Pharm Sin B. 2025 Apr;15(4):1773-1795. doi: 10.1016/j.apsb.2025.02.007. Epub 2025 Feb 11.
As the most abundant and essential structural protein in the human body, collagen is ubiquitously present in the interstitium of nearly all solid organs, playing a crucial role in maintaining the structural integrity and functional stability of human tissues and organs. Disorders associated with collagen structure and metabolisms impose a significant burden on society and healthcare systems. Post-translational modifications (PTMs) are essential steps in collagen metabolism, and recent studies have indicated that aberrant regulation of PTMs plays a pivotal role in the pathogenesis and progress of collagen-related disorders, including liver, kidney, heart, lung, and skin fibrosis, as well as keloid. This review provides a comprehensive summary of the regulatory mechanisms of both traditional and novel PTMs in collagen metabolism and collagen-related diseases. Furthermore, we summarize the drugs that modulate PTMs and their effects, with the aim of elucidating the pathophysiology of collagen-related diseases and provide new insights for their diagnosis, prevention, and treatment.
作为人体中含量最丰富且必不可少的结构蛋白，胶原蛋白广泛存在于几乎所有实体器官的间质中，在维持人体组织和器官的结构完整性与功能稳定性方面发挥着关键作用。与胶原蛋白结构和代谢相关的疾病给社会和医疗保健系统带来了沉重负担。翻译后修饰（PTMs）是胶原蛋白代谢中的关键步骤，最近的研究表明，PTMs的异常调控在包括肝、肾、心、肺和皮肤纤维化以及瘢痕疙瘩在内的胶原蛋白相关疾病的发病机制和进展中起着关键作用。本文综述了胶原蛋白代谢和胶原蛋白相关疾病中传统和新型PTMs的调控机制。此外，我们总结了调节PTMs的药物及其作用，旨在阐明胶原蛋白相关疾病的病理生理学，并为其诊断、预防和治疗提供新的见解。
