Division of Gastroenterology, Ludwig Demling Endoscopy Center of Excellence, University Hospital of Erlangen, Erlangen, Germany.
Department of Medicine, Division of Gastroenterology, Helios-Dr.-Horst-Schmidt-Kliniken, Wiesbaden, Germany.
Dig Endosc. 2018 Nov;30(6):730-738. doi: 10.1111/den.13251. Epub 2018 Aug 30.
Molecular imaging is based on the labelling of defined molecular targets through the utilization of fluorescently linked probes and their subsequent detection with high-resolution endoscopic devices, thereby enabling visualization of single molecules including receptors. Whereas early studies have used molecular imaging for improved visualization and detection of early dysplasia and cancer as well as for assessing intestinal inflammation and inflammation-associated cancer within the gastrointestinal (GI) tract, more recent studies have impressively demonstrated that molecular imaging can also be used to characterize and visualize the molecular fingerprint of cancer and inflammation in vivo and in real time. With this, molecular imaging can be used to guide expression-tailored individualized therapy. With the rapid expansion and diversification of the repertoire of biological agents utilized in inflammatory bowel disease and cancer, this approach is gaining increasing attention. Within this review, we first summarize the technical components commonly used for molecular imaging and then review preclinical and clinical studies and evolving clinical applications on molecular imaging within the lower GI tract. Molecular imaging has the potential to significantly change endoscopic diagnosis and subsequent targeted therapy of gastrointestinal cancer and chronic gastrointestinal diseases.
分子成像基于通过利用荧光连接探针对特定分子靶标进行标记，并随后使用高分辨率内窥镜设备进行检测，从而能够可视化单个分子，包括受体。虽然早期的研究已经使用分子成像来提高对早期发育不良和癌症的可视化和检测，以及评估胃肠道 (GI) 道中的肠道炎症和炎症相关癌症，但最近的研究令人印象深刻地表明，分子成像也可用于在体内实时表征和可视化癌症和炎症的分子指纹。通过这种方式，分子成像可用于指导基于表达的个体化治疗。随着在炎症性肠病和癌症中使用的生物制剂的 repertoire 的快速扩展和多样化，这种方法越来越受到关注。在本综述中，我们首先总结了常用于分子成像的技术组件，然后综述了关于下胃肠道分子成像的临床前和临床研究以及不断发展的临床应用。分子成像有可能显著改变胃肠道癌症和慢性胃肠道疾病的内镜诊断和随后的靶向治疗。
