Department of Medicine I, Division of Gastroenterology, Ludwig Demling Endoscopy Center of Excellence, University Hospital of Erlangen, Germany.
Department of Medicine I, Division of Gastroenterology, Ludwig Demling Endoscopy Center of Excellence, University Hospital of Erlangen, Germany.
Dig Liver Dis. 2018 Sep;50(9):878-885. doi: 10.1016/j.dld.2018.06.009. Epub 2018 Jun 23.
With the rapid expansion and diversification of the repertoire of biological agents utilized in inflammatory bowel diseases and cancer and the increase in oncological patients in gastroenterology, visualization of single receptor or molecular target expression and the subsequent initiation of expression tailored therapy are gaining increasing attention. Through the combination of utilizing fluorescently labeled probes with high specificity towards defined molecular targets and their subsequent detection and visualization with endoscopic devices, molecular imaging is a new emerging field focusing on the receptor expression within the mucosa on a cellular level rather than on macroscopic changes. In the past years various new technological and molecular probes have been successfully utilized for molecular imaging. Within this review, we summarize different technologies as well as molecular probes applied in molecular imaging and review current and past approaches for functional imaging with molecular endoscopy within the GI Tract and resulting clinical applications. It can be expected that molecular imaging allows for individualized diagnostic approaches and patient tailored medicine in the future.
随着生物制剂在炎症性肠病和癌症中的应用范围迅速扩大和多样化，以及胃肠病学中肿瘤患者的增加，对单一受体或分子靶标表达的可视化以及随后启动靶向表达治疗的关注度越来越高。通过将高特异性的荧光标记探针与明确的分子靶标结合，并利用内镜设备进行后续检测和可视化，分子成像成为一个新的研究领域，其专注于黏膜上的受体表达，而不是宏观变化。在过去的几年中，各种新技术和分子探针已成功用于分子成像。在这篇综述中，我们总结了不同的技术和分子探针在分子成像中的应用，并回顾了当前和过去在胃肠道中应用分子内镜进行功能成像的方法及其临床应用。可以预期，分子成像将在未来实现个体化诊断方法和针对患者的精准医疗。
