Waldner Maximilian J, Neurath Markus F
Department of Medicine 1, Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Deutsches Zentrum Immuntherapie (DZI), Friedrich-Alexander-Universität Erlangen-Nürnberg, Erlangen, Germany.
Front Oncol. 2022 Feb 25;12:835256. doi: 10.3389/fonc.2022.835256. eCollection 2022.
Colorectal cancer (CRC) is one of the leading causes of cancer related death in the western world. Its successful treatment requires early detection and removal of precursor lesions as well as individualized treatment of advanced disease. During recent years, molecular imaging techniques have shown promising results to improve current clinical practice. For instance, molecular endoscopy resulted in higher detection rates of precursors in comparison to conventional endoscopy in preclinical and clinical studies. Molecular confocal endomicroscopy allowed a further classification of suspect lesions as well as the prediction and monitoring of the therapeutic response. In this review, we summarize recent achievements for molecular imaging of CRC in preclinical studies, initial clinical trials and the remaining challenges for future translation into clinical practice.
结直肠癌（CRC）是西方世界癌症相关死亡的主要原因之一。其成功治疗需要早期检测和切除前驱病变以及对晚期疾病进行个体化治疗。近年来，分子成像技术已显示出有望改善当前临床实践的结果。例如，在临床前和临床研究中，分子内镜检查与传统内镜检查相比，前驱病变的检出率更高。分子共聚焦内镜检查能够对可疑病变进行进一步分类，以及对治疗反应进行预测和监测。在本综述中，我们总结了临床前研究、初步临床试验中结直肠癌分子成像的最新成果，以及未来转化为临床实践所面临的挑战。
