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1
Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-κ B and the serine/threonine kinase Akt and is independent of tubulin polymerization.姜黄素对紫杉醇诱导的细胞凋亡的致敏作用涉及核因子-κB和丝氨酸/苏氨酸激酶Akt的下调，且与微管蛋白聚合无关。
J Biol Chem. 2018 Aug 3;293(31):12283. doi: 10.1074/jbc.AAC118.004745.
2
Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-kappaB and the serine/threonine kinase Akt and is independent of tubulin polymerization.姜黄素对紫杉醇诱导的细胞凋亡的致敏作用涉及核因子-κB和丝氨酸/苏氨酸激酶Akt的下调，且与微管蛋白聚合无关。
J Biol Chem. 2005 Feb 25;280(8):6301-8. doi: 10.1074/jbc.M410647200. Epub 2004 Dec 7.
3
Curcumin-induced antiproliferative and proapoptotic effects in melanoma cells are associated with suppression of IkappaB kinase and nuclear factor kappaB activity and are independent of the B-Raf/mitogen-activated/extracellular signal-regulated protein kinase pathway and the Akt pathway.姜黄素对黑色素瘤细胞的抗增殖和促凋亡作用与IκB激酶和核因子κB活性的抑制有关，且独立于B-Raf/丝裂原活化/细胞外信号调节蛋白激酶途径和Akt途径。
Cancer. 2005 Aug 15;104(4):879-90. doi: 10.1002/cncr.21216.
4
Curcumin (diferuloylmethane) down-regulates the constitutive activation of nuclear factor-kappa B and IkappaBalpha kinase in human multiple myeloma cells, leading to suppression of proliferation and induction of apoptosis.姜黄素（二阿魏酰甲烷）可下调人多发性骨髓瘤细胞中核因子-κB和IκBα激酶的组成性激活，从而抑制细胞增殖并诱导细胞凋亡。
Blood. 2003 Feb 1;101(3):1053-62. doi: 10.1182/blood-2002-05-1320. Epub 2002 Sep 5.
5
Curcumin [1,7-bis(4-hydroxy-3-methoxyphenyl)-1-6-heptadine-3,5-dione; C21H20O6] sensitizes human prostate cancer cells to tumor necrosis factor-related apoptosis-inducing ligand/Apo2L-induced apoptosis by suppressing nuclear factor-kappaB via inhibition of the prosurvival Akt signaling pathway.姜黄素[1,7 - 双(4 - 羟基 - 3 - 甲氧基苯基)-1,6 - 庚二烯 - 3,5 - 二酮；C21H20O6]通过抑制促生存的Akt信号通路来抑制核因子 - κB，从而使人前列腺癌细胞对肿瘤坏死因子相关凋亡诱导配体/Apo2L诱导的凋亡敏感。
J Pharmacol Exp Ther. 2007 May;321(2):616-25. doi: 10.1124/jpet.106.117721. Epub 2007 Feb 8.
6
Potentiation of paclitaxel cytotoxicity in lung and esophageal cancer cells by pharmacologic inhibition of the phosphoinositide 3-kinase/protein kinase B (Akt)-mediated signaling pathway.通过药理学抑制磷酸肌醇3激酶/蛋白激酶B（Akt）介导的信号通路增强紫杉醇对肺癌和食管癌细胞的细胞毒性
J Thorac Cardiovasc Surg. 2004 Feb;127(2):365-75. doi: 10.1016/j.jtcvs.2003.09.033.
7
Curcumin-induced apoptosis in ovarian carcinoma cells is p53-independent and involves p38 mitogen-activated protein kinase activation and downregulation of Bcl-2 and survivin expression and Akt signaling.姜黄素诱导卵巢癌细胞凋亡与 p53 无关，涉及 p38 丝裂原活化蛋白激酶的激活以及下调 Bcl-2 和 survivin 的表达和 Akt 信号通路。
Mol Carcinog. 2010 Jan;49(1):13-24. doi: 10.1002/mc.20571.
8
Curcumin (diferuloylmethane) down-regulates expression of cell proliferation and antiapoptotic and metastatic gene products through suppression of IkappaBalpha kinase and Akt activation.姜黄素（二阿魏酰甲烷）通过抑制IκBα激酶和Akt激活，下调细胞增殖、抗凋亡和转移基因产物的表达。
Mol Pharmacol. 2006 Jan;69(1):195-206. doi: 10.1124/mol.105.017400. Epub 2005 Oct 11.
9
Curcumin dually inhibits both mammalian target of rapamycin and nuclear factor-κB pathways through a crossed phosphatidylinositol 3-kinase/Akt/IκB kinase complex signaling axis in adenoid cystic carcinoma.姜黄素通过交叉的磷脂酰肌醇 3-激酶/ Akt/IκB 激酶复合物信号轴双重抑制哺乳动物雷帕霉素靶蛋白和核因子-κB 通路在腺样囊性癌中。
Mol Pharmacol. 2011 Jan;79(1):106-18. doi: 10.1124/mol.110.066910. Epub 2010 Oct 19.
10
Nuclear factor-kappaB and IkappaB kinase are constitutively active in human pancreatic cells, and their down-regulation by curcumin (diferuloylmethane) is associated with the suppression of proliferation and the induction of apoptosis.核因子-κB和IκB激酶在人胰腺细胞中持续激活，姜黄素（二阿魏酰甲烷）对它们的下调与增殖抑制和凋亡诱导相关。
Cancer. 2004 Nov 15;101(10):2351-62. doi: 10.1002/cncr.20605.

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Phytochemicals as Potential Lead Molecules against Hepatocellular Carcinoma.植物化学物质作为潜在的肝癌先导分子。
Curr Med Chem. 2024;31(32):5199-5221. doi: 10.2174/0109298673275501231213063902.
2
Chronic Stress and Oxidative Stress as Common Factors of the Pathogenesis of Depression and Alzheimer's Disease: The Role of Antioxidants in Prevention and Treatment.慢性应激和氧化应激作为抑郁症和阿尔茨海默病发病机制的共同因素：抗氧化剂在预防和治疗中的作用
Antioxidants (Basel). 2021 Sep 9;10(9):1439. doi: 10.3390/antiox10091439.
3
Anticancer Mechanism of Curcumin on Human Glioblastoma.姜黄素对人胶质母细胞瘤的抗癌机制
Nutrients. 2021 Mar 16;13(3):950. doi: 10.3390/nu13030950.
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Co-Delivery of Docetaxel and Curcumin via Nanomicelles for Enhancing Anti-Ovarian Cancer Treatment.通过纳米胶束共递送多西他赛和姜黄素增强卵巢癌治疗。
Int J Nanomedicine. 2020 Dec 3;15:9703-9715. doi: 10.2147/IJN.S274083. eCollection 2020.
5
Beyond the Paclitaxel and Vinca Alkaloids: Next Generation of Plant-Derived Microtubule-Targeting Agents with Potential Anticancer Activity.超越紫杉醇和长春花生物碱：具有潜在抗癌活性的新一代植物源微管靶向剂。
Cancers (Basel). 2020 Jun 29;12(7):1721. doi: 10.3390/cancers12071721.

Sensitization of taxol-induced apoptosis by curcumin involves down-regulation of nuclear factor-κ B and the serine/threonine kinase Akt and is independent of tubulin polymerization.

作者信息

Bava Smitha V, Puliyappadamba Vineshkumar T, Deepti Ayswaria, Nair Asha, Karunagaran Devarajan, Anto Ruby John

出版信息

J Biol Chem. 2018 Aug 3;293(31):12283. doi: 10.1074/jbc.AAC118.004745.

DOI:10.1074/jbc.AAC118.004745
PMID:30076255
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6078455/
Abstract
摘要