Zhang Dangquan, Kanakkanthara Arun
College of Forestry, Henan Agricultural University, Zhengzhou 450002, Henan Province, China.
Division of Oncology Research, Mayo Clinic, Rochester, MN 55905, USA.
Cancers (Basel). 2020 Jun 29;12(7):1721. doi: 10.3390/cancers12071721.
Plants are an important source of chemically diverse natural products that target microtubules, one of the most successful targets in cancer therapy. Colchicine, paclitaxel, and vinca alkaloids are the earliest plant-derived microtubule-targeting agents (MTAs), and paclitaxel and vinca alkaloids are currently important drugs used in the treatment of cancer. Several additional plant-derived compounds that act on microtubules with improved anticancer activity are at varying stages of development. Here, we move beyond the well-discussed paclitaxel and vinca alkaloids to present other promising plant-derived MTAs with potential for development as anticancer agents. Various biological and biochemical aspects are discussed. We hope that the review will provide guidance for further exploration and identification of more effective, novel MTAs derived from plant sources.
植物是化学性质多样的天然产物的重要来源，这些天然产物作用于微管，而微管是癌症治疗中最成功的靶点之一。秋水仙碱、紫杉醇和长春花生物碱是最早的植物源微管靶向剂（MTA），紫杉醇和长春花生物碱目前是治疗癌症的重要药物。其他几种作用于微管且具有改善抗癌活性的植物源化合物正处于不同的开发阶段。在此，我们超越了已被充分讨论的紫杉醇和长春花生物碱，介绍其他有潜力作为抗癌药物开发的、有前景的植物源MTA。文中讨论了各种生物学和生物化学方面的内容。我们希望这篇综述能为进一步探索和鉴定更多有效的新型植物源MTA提供指导。
