Dewar J, Lunt H, Abernethy D A, Dady P, Haas L F
J Neurol Neurosurg Psychiatry. 1986 Jan;49(1):96-9. doi: 10.1136/jnnp.49.1.96.
Following chemotherapy with cis-diamminedichloroplatinum II (cisplatin) three patients developed Lhermitte's sign and peripheral neuropathy. The toxic side effects did not become apparent until after treatment had ceased. Because of increasing use of cisplatin to achieve lasting remission in patients with malignant disease proprioceptive and myelopathic side effects may become increasingly common.
在用顺二氯二氨铂(顺铂)进行化疗后,三名患者出现了莱尔米特征和周围神经病变。这些毒副作用直到治疗停止后才显现出来。由于越来越多地使用顺铂来使恶性疾病患者实现持久缓解,本体感觉和脊髓病副作用可能会变得越来越常见。