Department of Primary and Interdisciplinary Care (ELIZA), University of Antwerp, Universiteitsplein 1, Wilrijk, Antwerp, Belgium.
University Center of Geriatrics, General Hospital ZNA, Lindendreef 1, Antwerp, Belgium.
Aging Clin Exp Res. 2018 Nov;30(11):1297-1306. doi: 10.1007/s40520-018-1016-8. Epub 2018 Aug 4.
Physical decline and cognitive degeneration characterise the ageing process.
Physical parameters, performance and the functional indexes were studied in relation to age in healthy and cognitively impaired older persons to understand the interactions and changes during normal ageing, cognitive decline and progression to frailty.
Cross-sectional analysis was performed on a data registry of an ambulatory Memory Diagnosis Centre. The quantitative gait characteristics at usual pace, body composition parameters, disability scales (activity of daily living and instrumental activity of daily living) and Rockwood frailty index were compared in cognitively healthy (CHI), mild cognitively impaired, mildly and moderately demented < 80-years old and > 80-years old adults.
Quality of gait deteriorated with age in CHI and cognitively impaired. Skeletal muscle mass index decreased when cognitive status worsened. Disability and frailty correlated with increasing cognitive impairment. Age, gender, cognitive impairment, body composition and Rockwood's Frailty scale had a combined forecasting effect, as well as the individual effect on the gait characteristics. Disability score, Frailty index, skeletal muscle mass and skeletal muscle mass index, gait speed, normalised mean step length and swing time variability in mildly demented < 80-years old adults mirrored the parameters in the CHI > 80-years old.
Quantitative gait characteristics, muscle mass and disabilities change along with cognitive impairment, frailty and age. A more rapid physical ageing process accompanies cognitive decline. Therefore, gait characteristics should be age-referenced and studies on gait in older persons should include muscle mass, frailty and cognitive parameters.
身体机能下降和认知能力衰退是衰老过程的特征。
研究健康认知正常和认知受损老年人的身体参数、表现和功能指标与年龄的关系，以了解正常衰老、认知能力下降以及向衰弱发展过程中的相互作用和变化。
对一个门诊记忆诊断中心的数据登记进行横断面分析。比较认知正常（CHI）、轻度认知障碍、轻度和中度痴呆<80 岁和>80 岁成年人的常规步速下的定量步态特征、身体成分参数、残疾量表（日常生活活动和工具性日常生活活动）和 Rockwood 衰弱指数。
CHI 和认知受损者的步态质量随年龄增长而恶化。认知状态恶化时，骨骼肌质量指数下降。残疾和衰弱与认知障碍的加重相关。年龄、性别、认知障碍、身体成分和 Rockwood 的衰弱量表对步态特征具有综合预测作用，个体对步态特征的影响也是如此。在轻度痴呆<80 岁的成年人中，残疾评分、衰弱指数、骨骼肌质量和骨骼肌质量指数、步态速度、正常化平均步长和摆动时间变异性反映了 CHI>80 岁老年人的参数。
定量步态特征、肌肉质量和残疾随着认知障碍、衰弱和年龄而变化。认知衰退伴随着更快的身体衰老过程。因此，步态特征应该与年龄相关，老年人的步态研究应该包括肌肉质量、衰弱和认知参数。
