Lee Heon-Woo, Yu Pengchun, Simons Michael
Yale Cardiovascular Research Center, Section of Cardiovascular Medicine, Department of Internal Medicine, Yale University School of Medicine, New Haven, CT, USA.
F1000Res. 2018 Jul 20;7. doi: 10.12688/f1000research.14803.1. eCollection 2018.
The blood and lymphatic vasculatures are vital to the maintenance of homeostasis. The interaction between two vascular networks throughout the body is precisely controlled to enable oxygen and nutrient delivery, removal of carbon dioxide and metabolic waste, drainage of interstitial fluid, transport of immune cells, and other key activities. Recent years have seen an explosion of information dealing with the development and function of the lymphatic system. The growth of lymphatic vessels, termed lymphangiogenesis, is a high-energy requirement process that involves sprouting, proliferation, migration, and remodeling of lymphatic endothelial cells and capillaries. Although there has been substantial progress in identifying growth factors and their downstream signaling pathways that control lymphangiogenesis, the role of metabolic processes during lymphangiogenesis and their links to growth factor signaling are poorly understood. In this review, we will discuss recent work that has provided new insights into lymphatic metabolism and its role in lymphangiogenesis.
血液和淋巴脉管系统对于维持体内平衡至关重要。遍布全身的两个血管网络之间的相互作用受到精确控制，以实现氧气和营养物质的输送、二氧化碳和代谢废物的清除、间质液的引流、免疫细胞的运输以及其他关键活动。近年来，有关淋巴系统发育和功能的信息呈爆炸式增长。淋巴管的生长，即淋巴管生成，是一个高能量需求的过程，涉及淋巴管内皮细胞和毛细血管的发芽、增殖、迁移和重塑。尽管在识别控制淋巴管生成的生长因子及其下游信号通路方面取得了重大进展，但代谢过程在淋巴管生成中的作用及其与生长因子信号传导的联系仍知之甚少。在本综述中，我们将讨论最近的研究工作，这些工作为淋巴代谢及其在淋巴管生成中的作用提供了新的见解。
