Department of Bioinformatics, Matthias Schleiden Institute, Friedrich Schiller University Jena, Ernst-Abbe-Platz 2, 07743, Jena, Germany.
Institute of Zoology and Evolutionary Research, Friedrich Schiller University Jena, Erbertstraße 1, 07743, Jena, Germany.
Sci Rep. 2021 Mar 2;11(1):4938. doi: 10.1038/s41598-021-84061-8.
Aging research is a very popular field of research in which the deterioration or decline of various physiological features is studied. Here we consider the molecular level, which can also have effects on the macroscopic level. The proteinogenic amino acids differ in their susceptibilities to non-enzymatic modification. Some of these modifications can lead to protein damage and thus can affect the form and function of proteins. For this, it is important to know the distribution of amino acids between the protein shell/surface and the core. This was investigated in this study for all known structures of peptides and proteins available in the PDB. As a result, it is shown that the shell contains less susceptible amino acids than the core with the exception of thermophilic organisms. Furthermore, proteins could be classified according to their susceptibility. This can then be used in applications such as phylogeny, aging research, molecular medicine, and synthetic biology.
衰老研究是一个非常热门的研究领域，研究的是各种生理特征的恶化或衰退。在这里，我们考虑分子水平，它也可以对宏观水平产生影响。蛋白质氨基酸在非酶促修饰的易感性上有所不同。其中一些修饰会导致蛋白质损伤，从而影响蛋白质的形态和功能。为此，了解氨基酸在蛋白质壳/表面和核心之间的分布情况非常重要。本研究对 PDB 中所有已知的肽和蛋白质结构进行了这方面的研究。结果表明，除了嗜热生物外，蛋白质外壳中的氨基酸比核心中的氨基酸更不易受影响。此外，还可以根据蛋白质的易感性对其进行分类。这可以用于系统发育、衰老研究、分子医学和合成生物学等应用。
