路面密封剂产品中未取代多环芳烃和新型多环芳烃衍生物的鉴定与毒理学评估。
Identification and Toxicological Evaluation of Unsubstituted PAHs and Novel PAH Derivatives in Pavement Sealcoat Products.
作者信息
Titaley Ivan, Chlebowski Anna, Truong Lisa, Tanguay Robert L, Massey Simonicha Staci L
机构信息
Department of Chemistry, Oregon State University, Corvallis, OR, 97331, USA.
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR, 97331, USA.
出版信息
Environ Sci Technol Lett. 2016;3(6):234-242. Epub 2016 Apr 25.
Abstract
Pavement sealcoat products contain high concentrations of unsubstituted polycyclic aromatic hydrocarbons (PAHs), but the assessment of the potential toxicological impact is limited without the inclusion of PAH derivatives. This study determined the concentrations of 23 unsubstituted PAHs, 11 high molecular weight-PAHs (MW302-PAHs), and 56 PAH derivatives, including 10 methyl-PAHs (MPAHs), 10 heterocyclic-PAHs (Hetero-PAHs), 26 nitrated-PAHs (NPAHs), and 10 oxygenated-PAHs (OPAHs) in coal-tar and asphalt based sealcoat products and time point scrapes. Inclusion of MW302-PAHs resulted in an increase of 4.1-38.7% in calculated benzo[]pyrene-carcinogenic equivalent (B[]P) concentrations for the coal-tar based products. Increases in some NPAH and OPAH concentrations were measured after application, suggesting the possibility of photochemical transformation of unsubstituted PAHs. The Ames assay indicated that the asphalt based product was not mutagenic, but the coal-tar based sealcoat products were. The zebrafish developmental toxicity tests suggested that fractions where NPAHs and OPAHs eluted have the most significant adverse effects.
摘要
路面密封剂产品含有高浓度的未取代多环芳烃（PAHs），但如果不纳入PAH衍生物，对潜在毒理学影响的评估是有限的。本研究测定了煤焦油和沥青基密封剂产品及不同时间点刮取物中23种未取代PAHs、11种高分子量PAHs（MW302-PAHs）和56种PAH衍生物的浓度，其中包括10种甲基-PAHs（MPAHs）、10种杂环-PAHs（Hetero-PAHs）、26种硝化-PAHs（NPAHs）和10种含氧-PAHs（OPAHs）。纳入MW302-PAHs后，煤焦油基产品计算出的苯并[]芘致癌当量（B[]P）浓度增加了4.1%-38.7%。施用后测量到一些NPAH和OPAH浓度增加，这表明未取代PAHs可能发生光化学转化。艾姆斯试验表明，沥青基产品没有致突变性，但煤焦油基密封剂产品有。斑马鱼发育毒性试验表明，NPAHs和OPAHs洗脱的馏分具有最显著的不利影响。
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