斑马鱼：21世纪毒理学高通量生物学的奇迹。
Zebrafish: A marvel of high-throughput biology for 21 century toxicology.
作者信息
Bugel Sean M, Tanguay Robert L, Planchart Antonio
机构信息
Department of Environmental and Molecular Toxicology, Oregon State University, Corvallis, OR 97333.
Department of Biological Sciences, North Carolina State University, Raleigh, NC 27695.
出版信息
Curr Environ Health Rep. 2014 Sep 7;1(4):341-352. doi: 10.1007/s40572-014-0029-5.
Abstract
The evolutionary conservation of genomic, biochemical and developmental features between zebrafish and humans is gradually coming into focus with the end result that the zebrafish embryo model has emerged as a powerful tool for uncovering the effects of environmental exposures on a multitude of biological processes with direct relevance to human health. In this review, we highlight advances in automation, high-throughput (HT) screening, and analysis that leverage the power of the zebrafish embryo model for unparalleled advances in our understanding of how chemicals in our environment affect our health and wellbeing.
摘要
斑马鱼与人类在基因组、生物化学和发育特征方面的进化保守性正逐渐成为焦点，最终结果是斑马鱼胚胎模型已成为一种强大的工具，用于揭示环境暴露对众多与人类健康直接相关的生物过程的影响。在本综述中，我们重点介绍了自动化、高通量（HT）筛选和分析方面的进展，这些进展利用斑马鱼胚胎模型的强大功能，在我们理解环境中的化学物质如何影响我们的健康和福祉方面取得了无与伦比的进展。
相似文献
1
Zebrafish: A marvel of high-throughput biology for 21 century toxicology.
Curr Environ Health Rep. 2014 Sep 7;1(4):341-352. doi: 10.1007/s40572-014-0029-5.
2
Advancements in zebrafish applications for 21st century toxicology.
Pharmacol Ther. 2016 May;161:11-21. doi: 10.1016/j.pharmthera.2016.03.009. Epub 2016 Mar 22.
3
Computational toxicology as implemented by the U.S. EPA: providing high throughput decision support tools for screening and assessing chemical exposure, hazard and risk.
J Toxicol Environ Health B Crit Rev. 2010 Feb;13(2-4):197-217. doi: 10.1080/10937404.2010.483935.
4
Zebrafish in Toxicology and Environmental Health.
Curr Top Dev Biol. 2017;124:331-367. doi: 10.1016/bs.ctdb.2016.10.007. Epub 2016 Dec 21.
5
Zebrafish: as an integrative model for twenty-first century toxicity testing.
Birth Defects Res C Embryo Today. 2011 Sep;93(3):256-67. doi: 10.1002/bdrc.20214.
6
Using zebrafish in systems toxicology for developmental toxicity testing.
Congenit Anom (Kyoto). 2016 Jan;56(1):18-27. doi: 10.1111/cga.12142.
7
Automation of Technology for Cancer Research.
Adv Exp Med Biol. 2016;916:315-32. doi: 10.1007/978-3-319-30654-4_14.
8
The toxicological application of transcriptomics and epigenomics in zebrafish and other teleosts.
Brief Funct Genomics. 2014 Mar;13(2):157-71. doi: 10.1093/bfgp/elt053. Epub 2014 Jan 7.
9
Zebrafish: A tool for chemical screens.
Birth Defects Res C Embryo Today. 2010 Sep;90(3):185-92. doi: 10.1002/bdrc.20183.
10
Predictive models and computational toxicology.
Methods Mol Biol. 2013;947:343-74. doi: 10.1007/978-1-62703-131-8_26.
引用本文的文献
1
Small fish making a big difference: beloved star of environmental toxicology research in the current era.
J Zhejiang Univ Sci B. 2025 Jul 15;26(7):613-632. doi: 10.1631/jzus.B2500166.
2
Developmental and neurobehavioral toxicity of benzotriazole ultraviolet stabilizer UV-360 on zebrafish larvae.
PLoS One. 2025 May 23;20(5):e0324355. doi: 10.1371/journal.pone.0324355. eCollection 2025.
3
Zebrafish as a Suitable Model for Utilizing the Bioactivity of Coumarins and Coumarin-Based Compounds.
Int J Mol Sci. 2025 Feb 8;26(4):1444. doi: 10.3390/ijms26041444.
4
Unravelling the developmental toxicity of heavy metals using zebrafish as a model: a narrative review.
Biometals. 2025 Apr;38(2):419-463. doi: 10.1007/s10534-025-00671-z. Epub 2025 Feb 22.
5
Rapid determination of chemical losses in a microplate bioassay using fluorescence spectroscopy.
Anal Methods. 2025 Jan 16;17(3):514-524. doi: 10.1039/d4ay01980f.
6
An integrated approach to evaluating water contaminants and evaporation in agricultural water distribution systems.
Ecotoxicol Environ Saf. 2024 Nov 15;287:117277. doi: 10.1016/j.ecoenv.2024.117277. Epub 2024 Nov 7.
7
Deep autoencoder-based behavioral pattern recognition outperforms standard statistical methods in high-dimensional zebrafish studies.
PLoS Comput Biol. 2024 Sep 10;20(9):e1012423. doi: 10.1371/journal.pcbi.1012423. eCollection 2024 Sep.
8
Seminar: Functional Exposomics and Mechanisms of Toxicity-Insights from Model Systems and NAMs.
Environ Health Perspect. 2024 Sep;132(9):94201. doi: 10.1289/EHP13120. Epub 2024 Sep 4.
9
A review on current advancement in zebrafish models to study chronic inflammatory diseases and their therapeutic targets.
Heliyon. 2024 May 23;10(11):e31862. doi: 10.1016/j.heliyon.2024.e31862. eCollection 2024 Jun 15.
10
Assessing developmental and transcriptional effects of PM2.5 on zebrafish embryos.
Toxicol Rep. 2024 Mar 27;12:397-403. doi: 10.1016/j.toxrep.2024.03.011. eCollection 2024 Jun.
本文引用的文献
1
A rapid throughput approach identifies cognitive deficits in adult zebrafish from developmental exposure to polybrominated flame retardants.
Neurotoxicology. 2014 Jul;43:134-142. doi: 10.1016/j.neuro.2014.03.005. Epub 2014 Mar 24.
2
Studies on sensitivity of zebrafish as a model organism for Parkinson's disease: Comparison with rat model.
J Pharmacol Pharmacother. 2014 Jan;5(1):39-46. doi: 10.4103/0976-500X.124422.
3
Fishing for teratogens: a consortium effort for a harmonized zebrafish developmental toxicology assay.
Toxicol Sci. 2014 May;139(1):210-9. doi: 10.1093/toxsci/kfu017. Epub 2014 Feb 4.
4
Using zebrafish as a model system for studying the transgenerational effects of dioxin.
Toxicol Sci. 2014 Apr;138(2):403-11. doi: 10.1093/toxsci/kfu006. Epub 2014 Jan 27.
5
Toxicity assessment of TiO₂ nanoparticles in zebrafish embryos under different exposure conditions.
Aquat Toxicol. 2014 Feb;147:129-39. doi: 10.1016/j.aquatox.2013.12.024. Epub 2014 Jan 2.
6
High-content screening assay for identification of chemicals impacting spontaneous activity in zebrafish embryos.
Environ Sci Technol. 2014;48(1):804-10. doi: 10.1021/es404322p. Epub 2013 Dec 24.
7
Multidimensional in vivo hazard assessment using zebrafish.
Toxicol Sci. 2014 Jan;137(1):212-33. doi: 10.1093/toxsci/kft235. Epub 2013 Oct 17.
8
A new zebrafish model produced by TILLING of SOD1-related amyotrophic lateral sclerosis replicates key features of the disease and represents a tool for in vivo therapeutic screening.
Dis Model Mech. 2014 Jan;7(1):73-81. doi: 10.1242/dmm.012013. Epub 2013 Oct 2.
9
Exxon Valdez to Deepwater Horizon: comparable toxicity of both crude oils to fish early life stages.
Aquat Toxicol. 2013 Oct 15;142-143:303-16. doi: 10.1016/j.aquatox.2013.08.011. Epub 2013 Aug 31.
10
Imaging-based chemical screening reveals activity-dependent neural differentiation of pluripotent stem cells.
Elife. 2013 Sep 10;2:e00508. doi: 10.7554/eLife.00508.
Zotero 插件