Miki Kenju, Yoshimoto Misa
Department of Environmental Health, Life Science and Human Technology, Nara Women's University, Nara, Japan.
Front Neurosci. 2018 Jul 23;12:493. doi: 10.3389/fnins.2018.00493. eCollection 2018.
Exercise modulates arterial pressure (AP) regulation over various time spans. AP increases at the onset of exercise and this increase is then sustained during exercise. Once exercise is stopped, AP is suppressed for up to an hour afterwards. Prolonged endurance training is associated with dysfunction of the sympathetic regulation of AP in response to posture changes (orthostatic intolerance). Baroreflex control of sympathetic nerve activity (SNA) has been extensively studied to understand the mechanisms underlying exercise-induced changes in AP. We have previously presented entire baroreflex AP-SNA curves during and after exercise, and during central volume expansion, obtained using direct measurements of renal sympathetic nerve activity (RSNA) in conscious animals. In this review, we describe the modulatory effects of exercise on baroreflex control of AP based on these entire AP-RSNA baroreflex curves. We suggest that both acute and chronic exercise can have modulatory effects on the entire baroreflex curve for SNA, and that these effects differ among time periods.
运动在不同时间跨度内调节动脉血压（AP）的调节。运动开始时AP升高，且这种升高在运动过程中持续。一旦运动停止，AP随后会被抑制长达一小时。长期耐力训练与AP交感神经调节功能障碍有关，这种障碍是对姿势变化（体位性不耐受）的反应。为了理解运动引起的AP变化背后的机制，对压力反射对交感神经活动（SNA）的控制进行了广泛研究。我们之前在运动期间和运动后以及在中心血容量扩张期间，通过直接测量清醒动物的肾交感神经活动（RSNA），呈现了完整的压力反射AP-SNA曲线。在这篇综述中，我们基于这些完整的AP-RSNA压力反射曲线描述运动对AP压力反射控制的调节作用。我们认为，急性和慢性运动都可以对SNA的整个压力反射曲线产生调节作用，并且这些作用在不同时间段有所不同。
