Drieu Antoine, Levard Damien, Vivien Denis, Rubio Marina
Pathophysiology and Imaging of Neurological Disorders, Normandy University, Caen, France.
Pathophysiology and Imaging of Neurological Disorders, Normandy University, Caen, France Pathophysiology and Imaging of Neurological Disorders, Centre Hospitalier Universitaire de Caen, Caen, France.
Ther Adv Neurol Disord. 2018 Jul 30;11:1756286418789854. doi: 10.1177/1756286418789854. eCollection 2018.
So far, intravenous tissue-type plasminogen activator (tPA) and mechanical removal of arterial blood clot (thrombectomy) are the only available treatments for acute ischemic stroke. However, the short therapeutic window and the lack of specialized stroke unit care make the overall availability of both treatments limited. Additional agents to combine with tPA administration or thrombectomy to enhance efficacy and improve outcomes associated with stroke are needed. Stroke-induced inflammatory processes are a response to the tissue damage due to the absence of blood supply but have been proposed also as key contributors to all the stages of the ischemic stroke pathophysiology. Despite promising results in experimental studies, inflammation-modulating treatments have not yet been translated successfully into the clinical setting. This review will (a) describe the timing of the stroke immune pathophysiology; (b) detail the immune responses to stroke sift-through cell type; and
到目前为止，静脉注射组织型纤溶酶原激活剂（tPA）和机械清除动脉血栓（血栓切除术）是急性缺血性中风仅有的可用治疗方法。然而，治疗窗口短以及缺乏专业的中风单元护理使得这两种治疗方法的总体可及性有限。需要额外的药物与tPA给药或血栓切除术联合使用，以提高疗效并改善与中风相关的预后。中风引发的炎症过程是对因血液供应缺失导致的组织损伤的一种反应，但也被认为是缺血性中风病理生理学各个阶段的关键促成因素。尽管在实验研究中取得了令人鼓舞的结果，但炎症调节治疗尚未成功转化到临床应用中。本综述将（a）描述中风免疫病理生理学的时间进程；（b）详细阐述针对中风的免疫反应并按细胞类型进行梳理；以及
