O'Donohye T L, Handelmann G E, Miller R L, Jacobowitz D M
Science. 1982 Feb 26;215(4536):1125-7. doi: 10.1126/science.7063845.
A multineurotransmitter neuronal system that synthesizes and secretes both acetylated and deacetylated forms of alpha-melantropin and beta-endorphin is present in rat and human brain. The N-acetylated from of alpha-melanotropin had more potent behavioral effects than the deacetylated alpha-melanotropin. In the case of beta-endorphin, however, the deacetylated form has been shown to be more potent than the acetylated form. Enzymatic N-acetylation appears to be an important regulatory process for modulating the behavioral activity of peptides secreted from the opiomelanotropinergic multineurotransmitter neuron.
大鼠和人类大脑中存在一种多神经递质神经元系统，该系统能合成并分泌α-促黑素和β-内啡肽的乙酰化形式与去乙酰化形式。α-促黑素的N-乙酰化形式比去乙酰化的α-促黑素具有更强的行为效应。然而，就β-内啡肽而言，已表明去乙酰化形式比乙酰化形式更具效力。酶促N-乙酰化似乎是调节从阿片黑素皮质素能多神经递质神经元分泌的肽类行为活性的重要调节过程。
