以鳟鱼血红蛋白IV为例的一种大分子换能器。
A macromolecular transducer as illustrated by trout hemoglobin IV.
作者信息
Brunori M, Coletta M, Giardina B, Wyman J
出版信息
Proc Natl Acad Sci U S A. 1978 Sep;75(9):4310-2. doi: 10.1073/pnas.75.9.4310.
Abstract
Oxygen binding by trout Hb IV has been investigated as a function of pH up to 10 atmospheres (1 MPa) of pure O2. The results bring out an extreme proton-oxygen linkage, which gives rise to a Root effect. They are discussed in relation to the function of the hemoglobin as an oxygen pump. The system is of special interest as providing a prototype of a macromolecule acting as a transducer by coupling two allosterically linked reactions.
摘要
已经研究了虹鳟血红蛋白IV在高达10个大气压（1兆帕）纯氧条件下的氧结合情况与pH值的关系。结果显示出一种极端的质子 - 氧连接，这导致了鲁特效应。结合血红蛋白作为氧泵的功能对这些结果进行了讨论。该系统特别有趣，因为它提供了一个通过耦合两个变构连接反应作为传感器的大分子原型。
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