Lobmann M, Charlier P, Klaassen C L, Zygraich N
Am J Vet Res. 1986 Mar;47(3):557-60.
Safety tests were conducted in 78 pregnant cows vaccinated with a commercial preparation of a temperature-sensitive vaccine strain of bovine viral diarrhea (BVD) virus. After vaccination, seroconversion was detected in 33 (97%) of 34 cattle that did not have antibodies against BVD virus. Overall, 43 (91%) of 47 cows with prevaccination titers less than or equal to 4 seroconverted. During the test period, cows did not become naturally infected with BVD virus, and BVD-associated reactions to the vaccine were not observed in vaccinated cows. Calves born to vaccinated cows did not have clinical signs of fetal BVD. Precolostral blood samples collected from the progeny of cows that were seronegative at vaccination were free of antibody against BVD virus. Bovine viral diarrhea virus was not isolated from the cattle evaluated in the present study.
对78头接种了牛病毒性腹泻（BVD）病毒温度敏感疫苗株商业制剂的怀孕母牛进行了安全性测试。接种疫苗后，在34头对BVD病毒无抗体的牛中，有33头（97%）检测到血清转化。总体而言，47头接种前滴度小于或等于4的母牛中有43头（91%）发生了血清转化。在测试期间，母牛未自然感染BVD病毒，且在接种疫苗的母牛中未观察到与疫苗相关的BVD反应。接种疫苗的母牛所生的犊牛没有胎儿BVD的临床症状。从接种时血清阴性的母牛后代中采集的初乳前血样中没有抗BVD病毒抗体。在本研究评估的牛中未分离出牛病毒性腹泻病毒。
