Department of Cardiology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China.
Department of Cardiology, the People's Hospital of Guangxi Zhuang Autonomous Region, Nanning, China; Emergency & Critical Care Center, Beijing Anzhen Hospital, Capital Medical University, Beijing Institute of Heart, Lung, and Blood Vessel Diseases, Beijing 100029, China.
Clin Chim Acta. 2018 Nov;486:177-182. doi: 10.1016/j.cca.2018.08.005. Epub 2018 Aug 4.
Aortic dissection (AD) is one of the most dangerous forms of vascular disease, characterized by endometrial rupture and intramural hematoma formation. Generally, the pathological process is complicated and closely related to the infiltration of inflammatory cells into the aortic wall and apoptosis of vascular smooth muscle cells. Currently, multiple cytokines, including interleukins, interferon, the tumor necrosis factor superfamily, colony stimulating factor, chemotactic factor, growth factor and so on, have all been demonstrated to play a critical role in AD. Additionally, studies of the link between cytokines and AD could deepen our understanding of the disease and may guide future treatment therapies; therefore, this review focuses on the role of cytokines in AD.
主动脉夹层（AD）是最危险的血管疾病形式之一，其特征是内膜破裂和壁内血肿形成。一般来说，病理过程比较复杂，与炎症细胞浸润主动脉壁和血管平滑肌细胞凋亡密切相关。目前，多种细胞因子，包括白细胞介素、干扰素、肿瘤坏死因子超家族、集落刺激因子、趋化因子、生长因子等，都被证明在 AD 中发挥着关键作用。此外，细胞因子与 AD 之间关系的研究可以加深我们对这种疾病的认识，并可能指导未来的治疗方法；因此，本综述重点介绍细胞因子在 AD 中的作用。
