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视网膜分支静脉阻塞所致黄斑水肿抗VEGF治疗后视网膜内层的紊乱

Disorganization of the Retinal Inner Layers after Anti-VEGF Treatment for Macular Edema due to Branch Retinal Vein Occlusion.

作者信息

Nakano Eri, Ota Toru, Jingami Yoko, Nakata Isao, Hayashi Hisako, Yamashiro Kenji

出版信息

Ophthalmologica. 2018;240(4):229-234. doi: 10.1159/000490809. Epub 2018 Aug 8.

Abstract

PURPOSE

To evaluate the association between disorganization of the retinal inner layers (DRIL) and visual acuity (VA) after anti-VEGF treatment for macular edema (ME) due to branch retinal vein occlusion (BRVO).

METHODS

Sixty eyes of 60 patients were retrospectively investigated. Baseline characteristics and factors analyzed on optical coherence tomography (OCT) examination at the final visit were evaluated in association with VA at the final visit.

RESULTS

DRIL was detected in 39 eyes at the final visit. The central subfield thickness was significantly higher in the eyes with DRIL. While DRIL length at the final visit showed a significant association with final VA on univariable analysis, only age and ellipsoid zone disruption on OCT at the final visit were found to be significantly associated with VA on multivariable analysis.

CONCLUSIONS

DRIL had only a minor role in determining VA after anti-VEGF treatment for ME due to BRVO.

摘要

目的

评估视网膜内层紊乱(DRIL)与视网膜分支静脉阻塞(BRVO)所致黄斑水肿(ME)抗VEGF治疗后视力(VA)之间的关联。

方法

回顾性研究60例患者的60只眼。对末次随访时光学相干断层扫描(OCT)检查分析的基线特征和因素与末次随访时的视力进行关联评估。

结果

末次随访时在39只眼中检测到DRIL。存在DRIL的眼中中央子野厚度显著更高。单因素分析显示末次随访时DRIL长度与最终视力有显著关联,但多因素分析发现仅末次随访时的年龄和OCT上的椭圆体带破坏与视力显著相关。

结论

对于BRVO所致ME的抗VEGF治疗,DRIL在决定视力方面仅起次要作用。

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