Department of Biomedical Engineering, Purdue School of Engineering and Technology, Indiana University-Purdue University at Indianapolis, Indianapolis 46202, IN, USA.
J Biomater Appl. 2018 Sep;33(3):340-351. doi: 10.1177/0885328218792687. Epub 2018 Aug 8.
Antimicrobial surface is important for the inhibition of bacteria or biofilm formation on biomaterials. The objective of this study was to immobilize a novel hydrophilic polymer containing the antibacterial moiety onto polyurethane surface via a simple surface coating technology to make the surface not only antibacterial but also antifouling. The compound 3,4-dichloro-5-hydroxy-2(5H)-furanone was derivatized, characterized and incorporated onto polyvinylpyrrolidone containing succinimidyl functional groups, followed by coating onto the polyurethane surface. Contact angle, antibacterial function and protein adsorption of the modified surface were evaluated. The result shows that the modified surface exhibited significantly enhanced hydrophilicity with a 54-65% decrease in contact angle, increased antibacterial activity to Staphylococcus aureus, Staphylococcus epidermidis, and Pseudomonas aeruginosa with a 24-57% decrease in viability, and reduced human serum albumin adsorption with a 64-70% decrease in adsorption, as compared to the original polyurethane.
抗菌表面对于抑制生物材料上细菌或生物膜的形成非常重要。本研究的目的是通过简单的表面涂层技术将含有抗菌部分的新型亲水聚合物固定在聚氨酯表面上，使表面不仅具有抗菌性，而且还具有抗污性。将 3,4-二氯-5-羟基-2(5H)-呋喃酮衍生化、表征并掺入含有琥珀酰亚胺基官能团的聚乙烯基吡咯烷酮中，然后涂覆到聚氨酯表面上。评估了改性表面的接触角、抗菌功能和蛋白质吸附。结果表明，与原始聚氨酯相比，改性表面的亲水性显著增强，接触角降低了 54-65%，对金黄色葡萄球菌、表皮葡萄球菌和铜绿假单胞菌的抗菌活性提高了 24-57%，人血清白蛋白的吸附减少了 64-70%。
