Kemp J A, Downes C P
Brain Res. 1986 Apr 23;371(2):314-8. doi: 10.1016/0006-8993(86)90368-9.
Noradrenaline-stimulated inositol phospholipid breakdown in matched vibratome sections through the rat dorsal lateral geniculate nucleus (dLGN). The response was measured as a large accumulation of [3H]inositol labelled inositol monophosphate and was mediated via activation of alpha 1-adrenergic receptors. Accumulation of [3H]inositol phosphates was reduced in kainic acid-lesioned animals, indicating that this response occurred within dLGN neurones and not afferent terminals. The results implicate inositol phospholipid breakdown as part of the mechanism of noradrenergic neurotransmission within the dLGN.
去甲肾上腺素刺激大鼠背外侧膝状核（dLGN）匹配的振动切片中肌醇磷脂的分解。该反应通过[3H]肌醇标记的肌醇单磷酸的大量积累来测量，并通过α1-肾上腺素能受体的激活介导。在 kainic 酸损伤的动物中，[3H]肌醇磷酸的积累减少，表明这种反应发生在 dLGN 神经元内而非传入终末。结果表明肌醇磷脂分解是 dLGN 内去甲肾上腺素能神经传递机制的一部分。
