Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi 682041, India.
Centre for Nanosciences and Molecular Medicine, Amrita Institute of Medical Sciences and Research Centre, Amrita Vishwa Vidyapeetham, Kochi 682041, India.
Carbohydr Polym. 2018 Oct 15;198:385-400. doi: 10.1016/j.carbpol.2018.06.086. Epub 2018 Jun 23.
Carrageenan is a class of naturally occurring sulphated polysaccharides, which is currently a promising candidate in tissue engineering and regenerative medicine as it resemblances native glycosaminoglycans. From pharmaceutical drug formulations to tissue engineered scaffolds, carrageenan has broad range of applications. Here we provide an overview of developing various forms of carrageenan based hydrogels. We focus on how these fabrication processes has an effect on physiochemical properties of the hydrogel. We outline the application of these hydrogels not only pertaining to sustained drug release but also their application in bone and cartilage tissue engineering as well as in wound healing and antimicrobial formulations. Administration of these hydrogels through various routes for drug delivery applications has been critically reviewed. Finally, we conclude by summarizing the current and future outlook that promotes the seaweed-derived polysaccharide as versatile, promising biomaterial for a variety of bioengineering applications.
卡拉胶是一类天然存在的硫酸化多糖，因其类似于天然糖胺聚糖，目前是组织工程和再生医学中有前途的候选物。从药物制剂到组织工程支架，卡拉胶具有广泛的应用。在这里，我们提供了开发各种形式的卡拉胶基水凝胶的概述。我们重点介绍了这些制造工艺如何影响水凝胶的物理化学性质。我们概述了这些水凝胶的应用不仅涉及到药物的持续释放，还涉及到它们在骨和软骨组织工程以及伤口愈合和抗菌制剂中的应用。通过各种途径给药的这些水凝胶在药物输送应用中的应用已受到严格审查。最后，我们总结了当前和未来的前景，即促进海藻衍生多糖作为各种生物工程应用的多功能、有前途的生物材料。
