Ahmad Faheem, Nosheen Anum, Azam Farooq, Mushtaq Bushra, Ahmad Sheraz, Rasheed Abher, Nawab Yasir, Zafar Muhammad Sohail, Fareed Muhammad Amber, Shahwan Moyad
School of Engineering and Technology, National Textile University, Faisalabad, Pakistan.
Department of Clinical Sciences, College of Dentistry, Ajman University, Ajman, United Arab Emirates.
Heliyon. 2024 Sep 17;10(18):e37952. doi: 10.1016/j.heliyon.2024.e37952. eCollection 2024 Sep 30.
Hydrogels are used in modern wound dressings due to their ability to provide comfort with quick healing. However, poor mechanical properties of hydrogels limit their availability in commercial wound dressings. Nonwovens are highly porous, strong, and flexible structures that can provide support to hydrogels without compromising their properties. In this study, a cost-effective and sustainable hydroentangled nonwoven from industrial cotton waste was prepared and incorporated into alginate hydrogel for wound dressings. The novel composite of hydroentangled cotton nonwoven and alginate hydrogel was synthesized by a simple sol-gel technique. The effect of concentration of alginate hydrogel (0.5 wt%, 1 wt%, 1.5 wt %) and drying temperature (20 °C, 40 °C, 60 °C) of composite was analyzed for high wound exudates. The properties of prepared composite samples were characterized by scanning electron microscopy (SEM), XRD, tensile strength, tear strength, Air permeability, moisture management wound exudate test, and quantitative antimicrobial testing. Moreover, the comfort performance of these samples was evaluated by air permeability and moisture management testing. The properties of developed composites are highly dependent on the concentration of alginate and drying temperature. The results showed that maximum fluid absorbency (%) of 650 was achieved with good comfort properties. This study can help to increase the commercial availability of hydrogel-based wound dressings.
水凝胶因其能够在促进快速愈合的同时提供舒适感而被用于现代伤口敷料中。然而，水凝胶较差的机械性能限制了它们在商业伤口敷料中的应用。非织造布是高度多孔、坚固且灵活的结构，能够在不损害水凝胶性能的情况下为其提供支撑。在本研究中，制备了一种由工业棉废料制成的具有成本效益且可持续的水刺非织造布，并将其掺入藻酸盐水凝胶中用于伤口敷料。通过简单的溶胶-凝胶技术合成了水刺棉非织造布与藻酸盐水凝胶的新型复合材料。针对高伤口渗出液，分析了复合材料中藻酸盐水凝胶浓度（0.5 wt%、1 wt%、1.5 wt%）和干燥温度（20°C、40°C、60°C）的影响。通过扫描电子显微镜（SEM）、XRD、拉伸强度、撕裂强度、透气率、水分管理伤口渗出液测试和定量抗菌测试对制备的复合材料样品的性能进行了表征。此外，通过透气率和水分管理测试评估了这些样品的舒适性能。所开发复合材料的性能高度依赖于藻酸盐的浓度和干燥温度。结果表明，实现了650的最大液体吸收率（%），且具有良好的舒适性能。本研究有助于提高水凝胶基伤口敷料的商业可用性。
