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探索卡拉胶:从海藻到生物医学——全面综述。

Exploring carrageenan: From seaweed to biomedicine-A comprehensive review.

机构信息

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, India.

Department of Pharmaceutical Sciences and Technology, Birla Institute of Technology, Mesra, Ranchi 835215, India.

出版信息

Int J Biol Macromol. 2024 May;268(Pt 2):131822. doi: 10.1016/j.ijbiomac.2024.131822. Epub 2024 Apr 26.

Abstract

Biomaterials are pivotal in the realms of tissue engineering, regenerative medicine, and drug delivery and serve as fundamental building blocks. Within this dynamic landscape, polymeric biomaterials emerge as the frontrunners, offering unparalleled versatility across physical, chemical, and biological domains. Natural polymers, in particular, captivate attention for their inherent bioactivity. Among these, carrageenan (CRG), extracted from red seaweeds, stands out as a naturally occurring polysaccharide with immense potential in various biomedical applications. CRG boasts a unique array of properties, encompassing antiviral, antibacterial, immunomodulatory, antihyperlipidemic, antioxidant, and antitumor attributes, positioning it as an attractive choice for cutting-edge research in drug delivery, wound healing, and tissue regeneration. This comprehensive review encapsulates the multifaceted properties of CRG, shedding light on the chemical modifications that it undergoes. Additionally, it spotlights pioneering research that harnesses the potential of CRG to craft scaffolds and drug delivery systems, offering high efficacy in the realms of tissue repair and disease intervention. In essence, this review celebrates the remarkable versatility of CRG and its transformative role in advancing biomedical solutions.

摘要

生物材料在组织工程、再生医学和药物输送领域中起着关键作用,是基本的构建模块。在这个充满活力的领域中,聚合物生物材料脱颖而出,在物理、化学和生物领域提供无与伦比的多功能性。天然聚合物因其固有的生物活性而引起关注。其中,卡拉胶(CRG)是从红海藻中提取的天然多糖,具有巨大的潜力,在各种生物医学应用中崭露头角。CRG 具有一系列独特的特性,包括抗病毒、抗菌、免疫调节、抗高血脂、抗氧化和抗肿瘤特性,使其成为药物输送、伤口愈合和组织再生等前沿研究的理想选择。本综述全面概述了 CRG 的多方面特性,阐明了其经历的化学修饰。此外,它还重点介绍了利用 CRG 构建支架和药物输送系统的开创性研究,在组织修复和疾病干预领域具有很高的疗效。总之,本综述颂扬了 CRG 的卓越多功能性及其在推进生物医学解决方案方面的变革作用。

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