Department of Bioscience and Biotechnology, Microbial Carbohydrate Resource Bank (MCRB), Konkuk University, 120 Neungdong-ro, Gwangjin-gu, Seoul 05029, South Korea.
Institute for Ubiquitous Information Technology and Applications (UBITA), Center for Biotechnology Research in UBITA (CBRU), Konkuk University, Seoul 05029, South Korea.
Carbohydr Polym. 2018 Oct 15;198:563-574. doi: 10.1016/j.carbpol.2018.06.117. Epub 2018 Jun 28.
A novel self-healing hydrogel was prepared from a cationic β-cyclodextrin oligomer allyl ether [C(βCD-OM)AE] using a triple cross-linking strategy combining electrostatic interaction, host-guest complexation, and CC bonds as the macrocrosslinker. Here, the C(βCD-OM)AE@Ad gel was successfully prepared by polymerization of synthesized C(βCD-OM)AE, 1-adamantyl acrylate, and acrylic acid. The triple cross-linked hydrogel shows multi-functionality of high mechanical strength, enhanced stability, cytocompatibility, pH responsiveness as well as self-healing ability. Based on the cooperative and synergetic forces of non-covalent and covalent bonds, the C(βCD-OM)AE@Ad gel shows a high tensile strain up to 1,590%, and the self-healed gel could restore up to 84% of its initial length within 24 h. Furthermore, drug release in the hydrogel was controlled by the surrounding pH and slowly released. The present work reveals the cooperativity of multiple cross-links for a 3D structured polymeric material, and the developed self-healable hydrogel can possibly be applied in various biomedical applications.
一种新型自修复水凝胶是通过使用静电相互作用、主体-客体络合和 CC 键作为大交联剂的三重交联策略，从阳离子 β-环糊精低聚物烯丙基醚 [C(βCD-OM)AE] 制备的。在这里，通过合成的 C(βCD-OM)AE、1-金刚烷基丙烯酸酯和丙烯酸的聚合成功制备了 C(βCD-OM)AE@Ad 凝胶。该三重交联水凝胶具有高机械强度、增强的稳定性、细胞相容性、pH 响应性和自修复能力的多功能性。基于非共价和共价键的协同和协同力，C(βCD-OM)AE@Ad 凝胶表现出高达 1590%的高拉伸应变，自修复凝胶在 24 小时内可恢复其初始长度的 84%。此外，水凝胶中的药物释放受到周围 pH 值的控制并缓慢释放。本工作揭示了 3D 结构聚合物材料中多重交联的协同作用，开发的自修复水凝胶可能在各种生物医学应用中得到应用。
