Shin Hae Jin, Kang Sun Hyung, Moon Hee Seok, Sung Jae Kyu, Jeong Hyun Yong, Kim Ju Seok, Joo Jong Seok, Lee Eaum Seok, Kim Seok Hyun, Lee Byung Seok
Division of Gastroenterology, Department of Internal Medicine, Aerospace Medical Center, Republic of Korea Air Force, Cheongwon-gun, Chungcheongbuk-do Division of Gastroenterology, Department of Internal Medicine, Chungnam National University School of Medicine, Daejeon, Republic of Korea.
Medicine (Baltimore). 2018 Aug;97(32):e11795. doi: 10.1097/MD.0000000000011795.
In this study, we assess the possibility of using procalcitonin levels to differentiate between inflammatory diarrhea and non-inflammatory diarrhea in acute infectious diarrhea.We reviewed the records of 1176 patients who had symptoms of diarrhea, fever (≥37.8 °C), and abdominal pain between March 2011 and May 2015. After applying exclusion criteria, a sample of 514 patients was considered for study. The patient sample was divided into Group A and Group B for inflammatory diarrhea and non-inflammatory diarrhea, respectively. The assessment involved comparing the laboratory characteristics with the clinical characteristics of the groups.The characteristics of Group A, such as white blood cell (WBC), C-reactive protein (CRP), absolute neutrophil count (ANC), and procalcitonin levels, were relatively higher than those of Group B (P < .001 for Group A). A receiver operator characteristic (ROC) analysis revealed that the highest area-under-the-curve (AUC) value of procalcitonin (0.797; 95% confidence interval [CI] [0.760, 0.831]; P < .001), could be used to differentiate between the 2 groups. Procalcitonin exhibited a sensitivity and a specificity of 87.03% and 68.75%, respectively, at a 0.08 ng/mL cut-off level.Procalcitonin was a good candidate biomarker of inflammatory diarrhea than other inflammatory markers.
在本研究中，我们评估了使用降钙素原水平来区分急性感染性腹泻中的炎症性腹泻和非炎症性腹泻的可能性。我们回顾了2011年3月至2015年5月期间1176例有腹泻、发热（≥37.8°C）和腹痛症状患者的记录。应用排除标准后，选取了514例患者作为研究对象。将患者样本分别分为炎症性腹泻组（A组）和非炎症性腹泻组（B组）。评估内容包括比较两组的实验室特征和临床特征。A组的白细胞（WBC）、C反应蛋白（CRP）、绝对中性粒细胞计数（ANC）和降钙素原水平等特征相对高于B组（A组P<0.001）。受试者工作特征（ROC）分析显示，降钙素原的曲线下面积（AUC）最大值为0.797（95%置信区间[CI][0.760,0.831]；P<0.001），可用于区分两组。在截断水平为0.08 ng/mL时，降钙素原的敏感性和特异性分别为87.03%和68.75%。与其他炎症标志物相比，降钙素原是炎症性腹泻的良好候选生物标志物。
