Zhao Y, Hanton W K, Lee K H
J Nat Prod. 1986 Jan-Feb;49(1):139-42. doi: 10.1021/np50043a018.
The activity of the cytochrome oxidase, which is located in the plasma and the nuclear and the food-vacuole-limiting membranes as well as in the mitochondria of the trophozoites of Plasmodium berghei, was inhibited completely by sodium artesunate, an antimalarial drug, in vitro at 1 mM and in vivo at 100 mg/kg iv. This enzyme appears to be a target for the antimalarial mechanism of action of artesunate and qinghaosu.
疟原虫滋养体的血浆、细胞核、食物泡限制膜以及线粒体中所含的细胞色素氧化酶的活性，在体外1 mM时可被抗疟药青蒿琥酯完全抑制，在体内静脉注射100 mg/kg时也被完全抑制。这种酶似乎是青蒿琥酯和青蒿素抗疟作用机制的靶点。
