Jiang J B, Jacobs G, Liang D S, Aikawa M
Am J Trop Med Hyg. 1985 May;34(3):424-8. doi: 10.4269/ajtmh.1985.34.424.
The ultrastructural changes induced by the administration of the antimalarial drug, qinghaosu, were studied in monkeys (Macaca assamensis) infected with Plasmodium inui. Significant changes, notably mitochondrial swelling within the parasites but not within host cells, were first observed 2.5 hr after exposure to qinghaosu. This suggests that the target of qinghaosu may be the parasite's mitochondria, as occurs with primaquine. This is in contrast to the most widely used antimalarial drug, chloroquine.
在感染了三日疟原虫的猕猴（阿萨姆猕猴）中，研究了抗疟药物青蒿素给药后引起的超微结构变化。在接触青蒿素2.5小时后首次观察到显著变化，尤其是寄生虫体内的线粒体肿胀，但宿主细胞内没有。这表明青蒿素的作用靶点可能是寄生虫的线粒体，就像伯氨喹一样。这与使用最广泛的抗疟药物氯喹形成对比。
