Department of Research & Education, CIRO, Horn, The Netherlands.
NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht, The Netherlands.
NPJ Prim Care Respir Med. 2018 Aug 10;28(1):30. doi: 10.1038/s41533-018-0097-3.
Chronic obstructive pulmonary disease (COPD) is associated with substantial health impact that may already become apparent in early disease. This study aims to examine the features of subjects with COPD in a Dutch population-based sample and compare their physical status, mental status, and social status to non-COPD subjects. This study made use of Longitudinal Aging Study Amsterdam (LASA) data. Demographics, clinical characteristics, self-reported diseases, post-bronchodilator spirometry, physical, mental, and social status were assessed. A number of 810 subjects (50.5% male, mean age 60.5 ± 2.9 years) were included. Subjects with COPD (n = 68, mean FEV 67.6 [IQR 60.4-80.4] %.) had a slower walking speed than non-COPD subjects, p = 0.033. When compared to non-COPD subjects, COPD subjects gave a lower rating on their health (physical subscale of SF-12: 15 [IQR 16.0-19.0] vs. 18 [IQR 11.0-17.0] points) and life (EQ5D VAS: 75 [IQR 70.0-90.0] vs. 80 points [IQR 65.0-85.5]) surveys. COPD subjects also had a more impaired disease-specific health status (CAT: 9.5 ± 5.9 vs. 6.7 ± 5.2, respectively), were less likely to have a partner (69% vs. 84%, respectively) and received emotional support less often (24% vs. 36%, respectively) compared to non-COPD subjects (All comparisons p < 0.001). In a population-based sample, subjects with COPD had a reduced physical performance, a more impaired disease-specific health status and were more socially deprived compared to non-COPD subjects. These impairments need to be taken into consideration when setting up a management program for patients with mild COPD.
慢性阻塞性肺疾病（COPD）与重大健康影响相关，这些影响可能在疾病早期就已经显现。本研究旨在检查荷兰基于人群的样本中 COPD 患者的特征，并将他们的身体状况、精神状况和社会地位与非 COPD 患者进行比较。本研究利用了纵向老龄化研究阿姆斯特丹（LASA）的数据。评估了人口统计学、临床特征、自我报告的疾病、支气管扩张剂后肺量测定、身体、精神和社会状况。共纳入 810 名受试者（50.5%为男性，平均年龄 60.5±2.9 岁）。COPD 患者（n=68，平均 FEV 67.6[IQR 60.4-80.4]%）的步行速度比非 COPD 患者慢，p=0.033。与非 COPD 患者相比，COPD 患者在健康（SF-12 身体分量表：15[IQR 16.0-19.0]与 18[IQR 11.0-17.0]分）和生活（EQ5D VAS：75[IQR 70.0-90.0]与 80 分[IQR 65.0-85.5]）方面的评分较低。COPD 患者的疾病特异性健康状况也更差（CAT：9.5±5.9 与 6.7±5.2，分别），伴侣较少（69%与 84%，分别），情绪支持较少（24%与 36%，分别）。与非 COPD 患者相比（所有比较 p<0.001）。在基于人群的样本中，与非 COPD 患者相比，COPD 患者的身体活动能力降低，疾病特异性健康状况更差，社会剥夺程度更高。在为轻度 COPD 患者制定管理计划时，需要考虑到这些损害。
