亚治疗剂量的选择性5-羟色胺再摄取抑制剂（SSRI）类抗抑郁药显示出相当程度的5-羟色胺转运体占有率：对SSRI类药物逐渐减量的启示。 - Suppr

Suppr

超能文献

Subtherapeutic doses of SSRI antidepressants demonstrate considerable serotonin transporter occupancy: implications for tapering SSRIs.

作者信息

Shapiro Bryan B

机构信息

Department of Psychiatry and Human Behavior, UC Irvine Medical Center, Orange, CA, 92868, USA.

出版信息

Psychopharmacology (Berl). 2018 Sep;235(9):2779-2781. doi: 10.1007/s00213-018-4995-4. Epub 2018 Aug 10.

DOI:10.1007/s00213-018-4995-4

PMID:30097698

Abstract

摘要

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Subtherapeutic doses of SSRI antidepressants demonstrate considerable serotonin transporter occupancy: implications for tapering SSRIs.亚治疗剂量的选择性5-羟色胺再摄取抑制剂（SSRI）类抗抑郁药显示出相当程度的5-羟色胺转运体占有率：对SSRI类药物逐渐减量的启示。

Psychopharmacology (Berl). 2018 Sep;235(9):2779-2781. doi: 10.1007/s00213-018-4995-4. Epub 2018 Aug 10.

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本文引用的文献

Time-course of serotonin transporter occupancy by single dose of three SSRIs in human brain: A positron emission tomography study with [(11)C]DASB.单剂量三种 SSRIs 对人脑中 5-羟色胺转运体占有率的时间进程：用 [(11)C]DASB 进行的正电子发射断层扫描研究。

Psychiatry Res Neuroimaging. 2016 May 30;251:1-6. doi: 10.1016/j.pscychresns.2016.03.006. Epub 2016 Mar 28.

New Classification of Selective Serotonin Reuptake Inhibitor Withdrawal.选择性5-羟色胺再摄取抑制剂撤药的新分类

Psychother Psychosom. 2015;84(2):63-71. doi: 10.1159/000371865. Epub 2015 Feb 21.

Tablet splitting: a review of weight and content uniformity.片剂分割：重量与含量均匀度综述

Consult Pharm. 2012 May;27(5):341-52. doi: 10.4140/TCP.n.2012.341.

The mechanisms of tolerance in antidepressant action.抗抑郁作用中的耐受机制。

Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1593-602. doi: 10.1016/j.pnpbp.2010.07.026. Epub 2010 Aug 20.

Illness risk following rapid versus gradual discontinuation of antidepressants.抗抑郁药快速停药与逐渐停药后的疾病风险。

Am J Psychiatry. 2010 Aug;167(8):934-41. doi: 10.1176/appi.ajp.2010.09060880. Epub 2010 May 17.

Effects of the serotonin 1A, 2A, 2C, 3A, and 3B and serotonin transporter gene polymorphisms on the occurrence of paroxetine discontinuation syndrome.5-羟色胺 1A、2A、2C、3A 和 3B 受体及 5-羟色胺转运体基因多态性与帕罗西汀停药综合征发生的相关性研究。

J Clin Psychopharmacol. 2010 Feb;30(1):11-7. doi: 10.1097/JCP.0b013e3181c8ae80.

The effect of rate of antidepressant tapering on the incidence of discontinuation symptoms: a randomised study.抗抑郁药逐渐减药速度对停药症状发生率的影响：一项随机研究。

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J Psychopharmacol. 2008 Jul;22(5):581-4. doi: 10.1177/0269881107081562. Epub 2008 Jan 21.

Effects of gradual discontinuation of selective serotonin reuptake inhibitors in panic disorder with agoraphobia.在伴有广场恐惧症的惊恐障碍中逐渐停用选择性5-羟色胺再摄取抑制剂的效果。

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