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Subtherapeutic doses of SSRI antidepressants demonstrate considerable serotonin transporter occupancy: implications for tapering SSRIs.

作者信息

Shapiro Bryan B

机构信息

Department of Psychiatry and Human Behavior, UC Irvine Medical Center, Orange, CA, 92868, USA.

出版信息

Psychopharmacology (Berl). 2018 Sep;235(9):2779-2781. doi: 10.1007/s00213-018-4995-4. Epub 2018 Aug 10.

DOI:10.1007/s00213-018-4995-4
PMID:30097698
Abstract
摘要

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Time-course of serotonin transporter occupancy by single dose of three SSRIs in human brain: A positron emission tomography study with [(11)C]DASB.单剂量三种 SSRIs 对人脑中 5-羟色胺转运体占有率的时间进程：用 [(11)C]DASB 进行的正电子发射断层扫描研究。
Psychiatry Res Neuroimaging. 2016 May 30;251:1-6. doi: 10.1016/j.pscychresns.2016.03.006. Epub 2016 Mar 28.
2
New Classification of Selective Serotonin Reuptake Inhibitor Withdrawal.选择性5-羟色胺再摄取抑制剂撤药的新分类
Psychother Psychosom. 2015;84(2):63-71. doi: 10.1159/000371865. Epub 2015 Feb 21.
3
Tablet splitting: a review of weight and content uniformity.
Clin Pharmacol Ther. 2024 Apr;115(4):860-870. doi: 10.1002/cpt.3184. Epub 2024 Jan 31.
4
Adverse Effects of Antidepressant Medications and their Management in Children and Adolescents.抗抑郁药在儿童和青少年中的不良反应及其处理。
Pharmacotherapy. 2023 Jul;43(7):675-690. doi: 10.1002/phar.2767. Epub 2023 Jan 27.
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Short-course antidepressant therapy reduces discontinuation syndrome while maintaining treatment efficacy in patients with refractory functional dyspepsia: A randomized controlled trial.短程抗抑郁药治疗可减少难治性功能性消化不良患者的停药综合征，同时维持治疗效果：一项随机对照试验。
Front Psychiatry. 2022 Dec 8;13:1063722. doi: 10.3389/fpsyt.2022.1063722. eCollection 2022.
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Designing Flexible Longitudinal Regimens: Supporting Clinician Planning for Discontinuation of Psychiatric Drugs.设计灵活的纵向治疗方案：支持临床医生制定精神科药物停药计划。
Proc SIGCHI Conf Hum Factor Comput Syst. 2022 Apr;2022. doi: 10.1145/3491102.3502206. Epub 2022 Apr 29.
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Serotonin Reuptake Inhibitors and the Gut Microbiome: Significance of the Gut Microbiome in Relation to Mechanism of Action, Treatment Response, Side Effects, and Tachyphylaxis.血清素再摄取抑制剂与肠道微生物群：肠道微生物群在作用机制、治疗反应、副作用和快速耐受性方面的意义
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What I have learnt from helping thousands of people taper off antidepressants and other psychotropic medications.我从帮助成千上万的人逐渐停用抗抑郁药和其他精神药物中学到的东西。
Ther Adv Psychopharmacol. 2021 Mar 16;11:2045125321991274. doi: 10.1177/2045125321991274. eCollection 2021.
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The mechanisms of tolerance in antidepressant action.抗抑郁作用中的耐受机制。
Prog Neuropsychopharmacol Biol Psychiatry. 2011 Aug 15;35(7):1593-602. doi: 10.1016/j.pnpbp.2010.07.026. Epub 2010 Aug 20.
5
Illness risk following rapid versus gradual discontinuation of antidepressants.抗抑郁药快速停药与逐渐停药后的疾病风险。
Am J Psychiatry. 2010 Aug;167(8):934-41. doi: 10.1176/appi.ajp.2010.09060880. Epub 2010 May 17.
6
Effects of the serotonin 1A, 2A, 2C, 3A, and 3B and serotonin transporter gene polymorphisms on the occurrence of paroxetine discontinuation syndrome.5-羟色胺 1A、2A、2C、3A 和 3B 受体及 5-羟色胺转运体基因多态性与帕罗西汀停药综合征发生的相关性研究。
J Clin Psychopharmacol. 2010 Feb;30(1):11-7. doi: 10.1097/JCP.0b013e3181c8ae80.
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The effect of rate of antidepressant tapering on the incidence of discontinuation symptoms: a randomised study.抗抑郁药逐渐减药速度对停药症状发生率的影响：一项随机研究。
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Similar discontinuation symptoms for withdrawal from medium-dose paroxetine and venlafaxine after nine years in the same patient.同一患者在九年后出现了类似的因停用中等剂量帕罗西汀和文拉法辛而产生的戒断症状。
J Psychopharmacol. 2008 Jul;22(5):581-4. doi: 10.1177/0269881107081562. Epub 2008 Jan 21.
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Effects of gradual discontinuation of selective serotonin reuptake inhibitors in panic disorder with agoraphobia.在伴有广场恐惧症的惊恐障碍中逐渐停用选择性5-羟色胺再摄取抑制剂的效果。
Int J Neuropsychopharmacol. 2007 Dec;10(6):835-8. doi: 10.1017/S1461145706007462. Epub 2007 Jan 16.
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Antidepressant discontinuation syndrome.抗抑郁药停药综合征
Am Fam Physician. 2006 Aug 1;74(3):449-56.