Sposini Silvia, Hanyaloglu Aylin C
Institute of Reproductive and Developmental Biology, Department of Surgery and Cancer, Hammersmith Campus, Imperial College London, Du Cane Road, London, W12 0NN, UK.
Prog Mol Subcell Biol. 2018;57:273-299. doi: 10.1007/978-3-319-96704-2_10.
The G protein-coupled receptor (GPCR) superfamily activates complex signal pathways, yet untangling these signaling systems to understand how specificity in receptor signaling pathways is achieved, has been a challenging question. The roles of membrane trafficking in GPCR signal regulation has undergone a recent paradigm shift, from a mechanism that programs the plasma membrane G protein signaling profile to providing distinct signaling platforms critical for specifying receptor function in vivo. In this chapter, we discuss this evolution of our understanding in the endocytic trafficking systems employed by GPCRs, and how such systems play a deeply integrated role with signaling. We describe recent studies that suggest that the endomembrane compartment can provide a mechanism to both specify, and yet also diversify, GPCR signal transduction. These new evolving models could aid mechanistic understanding of complex disease and provide novel therapeutic avenues.
G蛋白偶联受体（GPCR）超家族可激活复杂的信号通路，然而，理清这些信号系统以了解受体信号通路中的特异性是如何实现的，一直是一个具有挑战性的问题。膜运输在GPCR信号调节中的作用最近经历了范式转变，从一种规划质膜G蛋白信号谱的机制转变为提供对体内受体功能特异性至关重要的独特信号平台。在本章中，我们将讨论我们对GPCR所采用的内吞运输系统理解的这一演变，以及这些系统如何与信号传导发挥深度整合作用。我们描述了最近的研究，这些研究表明内膜区室可以提供一种机制来特异性地确定GPCR信号转导，同时也使其多样化。这些新出现的模型有助于对复杂疾病的机制理解，并提供新的治疗途径。
