Asiaticoside counteracts the in vitro activation of microglia and astrocytes: Innuendo for multiple sclerosis.

BACKGROUND

During the development of Multiple Sclerosis (MS) there is a marked activation of microglia and astrocyte, leading to progressive inflammation and degeneration of myelin sheath which results in axonal loss and neuron damage.

PURPOSE

In this study, we have explored the action of Asiaticoside A against the activated microglia and astrocytes.

METHODS

Primary microglia and astrocyte cultures were used for the study and the activity were evaluated using cell proliferation assay, nitrate assay and TNFα estimation using ELISA.

RESULTS

Asiaticoside A inhibited the production of nitric oxide and TNFα in LPS activated primary microglia and astrocyte cultures.

CONCLUSION

This study suggests that Asiaticoside A may be effective against the progression of MS.