Department of Pharmaceutical Chemistry, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timişoara, Romania.
Department of Pharmaceutical Botany, Faculty of Pharmacy, Victor Babeş University of Medicine and Pharmacy, 2nd Eftimie Murgu Sq., 300041 Timişoara, Romania.
Molecules. 2020 Nov 26;25(23):5557. doi: 10.3390/molecules25235557.
Wounds are among the most common skin conditions, displaying a large etiological diversity and being characterized by different degrees of severity. Wound healing is a complex process that involves multiple steps such as inflammation, proliferation and maturation and ends with scar formation. Since ancient times, a widely used option for treating skin wounds are plant- based treatments which currently have become the subject of modern pharmaceutical formulations. Triterpenes with tetracyclic and pentacyclic structure are extensively studied for their implication in wound healing as well as to determine their molecular mechanisms of action. The current review aims to summarize the main results of in vitro, in vivo and clinical studies conducted on lupane, ursane, oleanane, dammarane, lanostane and cycloartane type triterpenes as potential wound healing treatments.
伤口是最常见的皮肤状况之一，具有广泛的病因多样性，并表现出不同程度的严重程度。伤口愈合是一个复杂的过程，涉及多个步骤，如炎症、增殖和成熟，并以瘢痕形成结束。自古以来，植物治疗一直是治疗皮肤伤口的常用方法，目前已成为现代药物制剂的研究对象。四环和五环结构的三萜类化合物因其在伤口愈合中的作用以及确定其作用的分子机制而被广泛研究。目前的综述旨在总结对羽扇豆烷、乌苏烷、齐墩果烷、达玛烷、羊毛甾烷和环阿屯烷型三萜类化合物作为潜在伤口愈合治疗的体外、体内和临床研究的主要结果。
