Laboratory Research on Biological Systems and Geomatics, Faculty of Nature and Life, University of Mascara, Algeria.
Instituto de Biología Molecular y Celular del Cáncer and CIBERONC, CSIC-Universidad de Salamanca, Campus Miguel de Unamuno, Salamanca, Spain.
Biomed Pharmacother. 2018 Nov;107:408-423. doi: 10.1016/j.biopha.2018.08.006. Epub 2018 Aug 9.
Colorectal cancer is one of the most frequent malignancies in the world. Although recent advances in chemotherapy have improved management and survival of colorectal cancer patients, side effects and resistance to chemotherapy have shown the limitations of current chemotherapy and led to the search for alternative treatments. In this context, medicinal plants provide a large number of molecules with proven cytotoxic and apoptogenic activities against several types of cancers including colorectal cancer. These molecules belong to various phytochemical families and trigger different signaling pathways. Here, we review the recent findings regarding the anti-colorectal cancer activities of several plants, both in vitro and in vivo, and the phytochemical molecules possibly responsible for these activities. Besides, their effects on several cancer signaling pathways are discussed. This review highlights the importance of medicinal plants as promising sources of lead anti-colorectal molecules.
结直肠癌是世界上最常见的恶性肿瘤之一。尽管最近在化疗方面的进展改善了结直肠癌患者的治疗和生存情况，但化疗的副作用和耐药性显示出了当前化疗的局限性，并促使人们寻找替代治疗方法。在这种情况下，药用植物提供了大量的分子，这些分子已被证明对包括结直肠癌在内的多种类型的癌症具有细胞毒性和促凋亡活性。这些分子属于各种植物化学家族，并触发不同的信号通路。在这里，我们综述了近年来关于几种植物在体外和体内抗结直肠癌活性的研究结果，以及可能导致这些活性的植物化学分子。此外，还讨论了它们对几种癌症信号通路的影响。本综述强调了药用植物作为有前途的抗结直肠癌先导分子来源的重要性。
