Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Stress Research Institute, Stockholm University, Stockholm, Sweden.
Department of Clinical Neuroscience, Karolinska Institute, Stockholm, Sweden; Stress Research Institute, Stockholm University, Stockholm, Sweden.
Sleep Med. 2018 Nov;51:80-84. doi: 10.1016/j.sleep.2018.07.004. Epub 2018 Aug 10.
Combined insomnia and obstructive sleep apnea has been the focus of considerable research with respect to its health effects. A related issue is whether sleep disturbances in combination with snoring might exert effects on objective sleep variables in the non-clinical general population. The purpose of the present study was to investigate the polysomnographical characteristics of individuals who had sought medical help for both disturbed sleep and for snoring. No previous work of this type has been carried out.
For this study we used a representative set of data of 384 women with one night of in-home PSG. We identified those individuals who had sought medical help for sleep problems (SL), individuals that had sought help for snoring (SN), as well as those that had sought help for either both (Combined), or for neither (Control).
Our results yielded an N of 46, 16, 21, and 301 individuals, respectively. A one-factor analysis of variance showed significant main effects on N1% (F = 10.2, p < 0.001), N3% (F = 2.7, p < 0.05), AHI/h (F = 5.5, p < 0.001), and a delta power measure (F = 3.8, p < 0.05). The combined group showed significantly higher levels than the other groups for N1% (29% vs < 21%), AHI/h (19/h vs < 10/h) and lower levels for N3%, and a measure of delta power. Reported sleep quality measures did not show the same pattern, since the highest/lowest value were found for either the group presenting snoring alone or sleep problems alone.
We concluded that individuals who had sought help for both insomnia and snoring showed impaired sleep in terms of PSG and that this was not reflected in ratings of sleep or health. This suggests that simultaneous sleep disturbances and snoring may potentiate each other to cause impaired sleep, yet the mechanism still needs to be elucidated.
合并的失眠和阻塞性睡眠呼吸暂停一直是相当多的研究的重点，对其健康影响。一个相关的问题是，睡眠障碍是否与打鼾相结合可能会对非临床普通人群的客观睡眠变量产生影响。本研究的目的是调查因睡眠和打鼾而寻求医疗帮助的个体的多导睡眠图特征。以前没有进行过这种类型的工作。
为此，我们使用了一组有 384 名女性的代表性数据，这些女性进行了一夜的家庭多导睡眠图检查。我们确定了那些因睡眠问题（SL）而寻求医疗帮助的个体，那些因打鼾（SN）而寻求医疗帮助的个体，以及那些同时因两者（合并）或两者都不（对照）而寻求医疗帮助的个体。
我们的结果分别得到了 46、16、21 和 301 名个体的结果。单因素方差分析显示，N1%（F=10.2，p<0.001）、N3%（F=2.7，p<0.05）、AHI/h（F=5.5，p<0.001）和一个 delta 功率测量值（F=3.8，p<0.05）有显著的主效应。合并组的 N1%（29%对<21%）、AHI/h（19/h 对<10/h）显著高于其他组，N3%和 delta 功率测量值则较低。报告的睡眠质量测量值没有表现出相同的模式，因为睡眠问题或打鼾单独出现的组的睡眠质量测量值最高/最低。
我们得出结论，因失眠和打鼾同时寻求医疗帮助的个体在多导睡眠图上表现出睡眠受损，而这并没有反映在睡眠或健康的评估中。这表明同时存在睡眠障碍和打鼾可能会相互增强，从而导致睡眠受损，但仍需要阐明其机制。
