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《HIV 感染者癌症》第 1.2018 版,NCCN 肿瘤学临床实践指南。

Cancer in People Living With HIV, Version 1.2018, NCCN Clinical Practice Guidelines in Oncology.

出版信息

J Natl Compr Canc Netw. 2018 Aug;16(8):986-1017. doi: 10.6004/jnccn.2018.0066.

Abstract

People living with HIV (PLWH) are diagnosed with cancer at an increased rate over the general population and generally have a higher mortality due to delayed diagnoses, advanced cancer stage, comorbidities, immunosuppression, and cancer treatment disparities. Lack of guidelines and provider education has led to substandard cancer care being offered to PLWH. To fill that gap, the NCCN Guidelines for Cancer in PLWH were developed; they provide treatment recommendations for PLWH who develop non-small cell lung cancer, anal cancer, Hodgkin lymphoma, and cervical cancer. In addition, the NCCN Guidelines outline advice regarding HIV management during cancer therapy; drug-drug interactions between antiretroviral treatments and cancer therapies; and workup, radiation therapy, surgical management, and supportive care in PLWH who have cancer.

摘要

HIV 感染者(PLWH)的癌症诊断率高于普通人群,由于诊断延迟、癌症晚期、合并症、免疫抑制和癌症治疗差异,死亡率通常更高。缺乏指南和提供者教育导致向 PLWH 提供的癌症护理标准不高。为了填补这一空白,制定了 NCCN 指南用于 PLWH 中的癌症治疗;它们为患有非小细胞肺癌、肛门癌、霍奇金淋巴瘤和宫颈癌的 PLWH 提供了治疗建议。此外,NCCN 指南概述了癌症治疗期间 HIV 管理方面的建议;抗逆转录病毒治疗与癌症治疗之间的药物相互作用;以及 PLWH 癌症患者的检查、放射治疗、手术管理和支持性护理。

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