Department of Respiratory Medicine, NUTRIM School of Nutrition and Translational Research in Metabolism, Maastricht University Medical Centre, Maastricht, The Netherlands.
Department of Pulmonary Diseases, University of Groningen, University Medical Centre Groningen, Groningen, The Netherlands.
Thorax. 2019 Feb;74(2):206-207. doi: 10.1136/thoraxjnl-2018-211931. Epub 2018 Aug 12.
Muscle wasting frequently occurs in severe emphysema. Improving respiratory mechanics by bronchoscopic lung volume reduction using endobronchial valves (EBV) might prevent further loss or even increase in muscle mass. CT-derived skeletal muscle mass gain was observed in 39/49 patients 6 months after EBV. Multiple linear regression showed that gain in muscle (β=2.4; 95% CI 0.2 to 4.6; p=0.036) and intramuscular fat (β=3.1; 95% CI 0.2 to 5.9; p=0.035) is associated with improved 6 min walk distance independent of the change in residual volume. Skeletal muscle remodelling associates with improved exercise capacity after EBV, independent of hyperinflation reduction. TRIAL REGISTRATION NUMBER: Clinical trial registered with the Dutch trial register www.trialregister.nl (NTR2876), Results.
严重肺气肿常伴有肌肉消耗。通过支气管镜肺减容术(endobronchial valve，EBV)改善呼吸力学，可能防止肌肉进一步丢失，甚至增加肌肉量。支气管镜肺减容术后 6 个月，49 例患者中有 39 例 CT 显示骨骼肌量增加。多元线性回归显示，肌肉增加（β=2.4；95%CI 0.2 至 4.6；p=0.036）和肌内脂肪增加（β=3.1；95%CI 0.2 至 5.9；p=0.035）与 6 分钟步行距离的改善独立相关，而与残气量的变化无关。骨骼肌重塑与 EBV 后运动能力的改善相关，与过度充气减少无关。试验注册号：荷兰临床试验注册中心 www.trialregister.nl（NTR2876），结果。
