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Antimicrobial resistance: capacity and practices among clinical laboratories in Kenya, 2013.2013年肯尼亚临床实验室的抗菌药物耐药性:能力与实践
Pan Afr Med J. 2014 Nov 27;19:332. doi: 10.11604/pamj.2014.19.332.5159. eCollection 2014.
2
Practice of switch from intravenous to oral antibiotics.从静脉注射抗生素转换为口服抗生素的实践。
Springerplus. 2014 Dec 9;3:717. doi: 10.1186/2193-1801-3-717. eCollection 2014.
3
Improving antimicrobial prescribing: implementation of an antimicrobial i.v.-to-oral switch policy.改善抗菌药物处方:抗菌药物静脉转口服转换政策的实施
J R Coll Physicians Edinb. 2013;43(4):294-300. doi: 10.4997/JRCPE.2013.403.
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Critical evaluation of antimicrobial use--a Turkish university hospital example.抗菌药物使用的批判性评估——以一家土耳其大学医院为例
J Infect Dev Ctries. 2013 Nov 15;7(11):873-9. doi: 10.3855/jidc.2921.
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Interventions to improve antibiotic prescribing practices for hospital inpatients.改善医院住院患者抗生素处方行为的干预措施。
Cochrane Database Syst Rev. 2013 Apr 30(4):CD003543. doi: 10.1002/14651858.CD003543.pub3.
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An audit of prophylactic surgical antibiotic use in a Sudanese Teaching Hospital.在苏丹教学医院进行预防性外科抗生素使用的审核。
Int J Clin Pharm. 2013 Feb;35(1):149-53. doi: 10.1007/s11096-012-9719-y. Epub 2012 Nov 8.
7
Improving the quality of antibiotic prescribing in the NHS by developing a new Antimicrobial Stewardship Programme: Start Smart--Then Focus.通过开发新的抗菌药物管理计划来提高国民保健制度中抗生素处方的质量:从明智开始——然后聚焦。
J Antimicrob Chemother. 2012 Jul;67 Suppl 1:i51-63. doi: 10.1093/jac/dks202.
8
Different patterns of inappropriate antimicrobial use in surgical and medical units at a tertiary care hospital in Switzerland: a prevalence survey.瑞士一家三级保健医院外科和内科科室中不适当使用抗菌药物的不同模式:一项患病率调查。
PLoS One. 2010 Nov 16;5(11):e14011. doi: 10.1371/journal.pone.0014011.
9
Benchmarking antimicrobial drug use at university hospitals in five European countries.对欧洲五个国家大学医院抗菌药物使用情况进行基准比对。
Clin Microbiol Infect. 2007 Mar;13(3):277-83. doi: 10.1111/j.1469-0691.2006.01613.x.
10
Intravenous to oral antibiotic switch therapy.静脉至口服抗生素转换疗法。
Drugs Today (Barc). 2001 May;37(5):311-319. doi: 10.1358/dot.2001.37.5.627953.

肯尼亚西部一家乡村医院外科的抗生素使用情况审计。

An antibiotic audit of the surgical department at a rural hospital in Western Kenya.

作者信息

Talaam Ruth Chepkemoi, Abungana Michael Mudeheri, Ooko Philip Blasto

机构信息

Department of Surgery, AIC Litein Hospital, Litein, Kenya.

出版信息

Pan Afr Med J. 2018 Apr 23;29:219. doi: 10.11604/pamj.2018.29.219.14510. eCollection 2018.

DOI:10.11604/pamj.2018.29.219.14510
PMID:30100973
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6080977/
Abstract

INTRODUCTION

Antibiotics are one of the most commonly prescribed medications in hospitalized patients, with up to half of prescriptions being irrational. This study aimed to assess the quality of antibiotic use among surgical inpatients at our institution.

METHODS

A one year (January 1-December 31, 2015) retrospective chart review on antibiotic use for patients admitted to the surgical department at AIC Litein Hospital, a faith based non-governmental health institution in Western Kenya, was conducted. Data were collected from medical and nursing patient charts with a standardized questionnaire. The criteria applied to assess inappropriate antibiotic use focused on the choice, duration and indication of the antibiotics prescribed.

RESULTS

A total of 394 cases were evaluated, with a mean age of 44.8 years and a mean duration of hospitalization of 7.2 days. Antibiotics were initiated either for prophylaxis (205, 56.3%) or treatment (159, 43.7%) for a mean duration of 6 days (range 1-37). The predominant route of administration was intravenous (332, 91.2%). Most antibiotics started at admission were continued till discharge and the duration of antibiotics was indicated in only 11% of the treatment sheets. At discharge, 321 (81.4%) cases had antibiotics prescribed for a mean duration of 5.7 days (range 1-60). Inappropriate prescriptions were noted in 45.4% of prophylactic antibiotics, 33.4% treatment antibiotics and 52.6% of discharge antibiotics. The most common reason for inappropriate antibiotic use during hospitalization was inappropriate duration (45.9%).

CONCLUSION

Proper documentation, daily antibiotic review and preparation of a local antibiotic policy guideline could help improve the appropriate use of antibiotics.

摘要

引言

抗生素是住院患者中最常用的处方药之一,高达一半的处方存在不合理性。本研究旨在评估我院外科住院患者的抗生素使用质量。

方法

对肯尼亚西部一家基于信仰的非政府卫生机构AIC Litein医院外科收治患者的抗生素使用情况进行了为期一年(2015年1月1日至12月31日)的回顾性病历审查。通过标准化问卷从医疗和护理病历中收集数据。评估不当抗生素使用的标准侧重于所开抗生素的选择、疗程和适应证。

结果

共评估了394例病例,平均年龄44.8岁,平均住院时间7.2天。抗生素用于预防(205例,56.3%)或治疗(159例,43.7%),平均疗程6天(范围1 - 37天)。主要给药途径为静脉注射(332例,91.2%)。大多数入院时开始使用的抗生素持续至出院,只有11%的治疗单注明了抗生素疗程。出院时,321例(81.4%)患者开具了抗生素,平均疗程5.7天(范围1 - 60天)。预防性抗生素中有45.4%、治疗性抗生素中有33.4%以及出院时使用的抗生素中有52.6%存在不当处方。住院期间抗生素使用不当的最常见原因是疗程不当(45.9%)。

结论

妥善记录、每日抗生素审查以及制定当地抗生素政策指南有助于改善抗生素的合理使用。