Nakamura Kohei, Nakayama Kentaro, Tatsumi Nagisa, Minamoto Toshiko, Ishibashi Tomoka, Ohnishi Kaori, Yamashita Hitomi, Ono Ruriko, Sasamori Hiroki, Razia Sultana, Kamrunnahar Shanta, Ishikawa Masako, Kyo Satoru
Department of Obstetrics and Gynecology, Shimane University School of Medicine, Izumo, Shimane 690-8504, Japan.
Mol Clin Oncol. 2018 Aug;9(2):138-144. doi: 10.3892/mco.2018.1646. Epub 2018 Jun 5.
The aim of the present study was to assess the prognostic significance of the pre-treatment neutrophil-to-lymphocyte ratio (NLR), the platelet-to-lymphocyte ratio (PLR) and other clinicopathological characteristics in patients with non-surgically treated uterine cervical carcinoma. The correlations of clinicopathological characteristics with overall and progression-free survival were determined in 98 Japanese patients who received non-surgical treatment for uterine cervical carcinoma between January 1997 and July 2013. Survival rates were calculated using the Kaplan-Meier method and potential prognostic indicators were assessed using a Cox proportional hazards model. A total of 68 patients (69.4%) had a high pre-treatment NLR (≥3.5) and 34 patients (34.7%) had a high pre-treatment PLR (≥212). Both NLR and PLR were found to be positively correlated with pre-treatment platelet counts. Multivariate analysis identified NLR and carcinoembryonic antigen level, but not PLR, as independent predictors of overall and progression-free survival. In conclusion, the present study identified two prognostic indicators for uterine cervical carcinoma, both of which can be easily and cost-effectively monitored via blood testing.
本研究的目的是评估治疗前中性粒细胞与淋巴细胞比值（NLR）、血小板与淋巴细胞比值（PLR）以及其他临床病理特征对非手术治疗子宫颈癌患者的预后意义。在1997年1月至2013年7月期间接受子宫颈癌非手术治疗的98例日本患者中，确定了临床病理特征与总生存期和无进展生存期的相关性。采用Kaplan-Meier法计算生存率，并使用Cox比例风险模型评估潜在的预后指标。共有68例患者（69.4%）治疗前NLR较高（≥3.5），34例患者（34.7%）治疗前PLR较高（≥212）。发现NLR和PLR均与治疗前血小板计数呈正相关。多变量分析确定NLR和癌胚抗原水平而非PLR是总生存期和无进展生存期的独立预测因素。总之，本研究确定了子宫颈癌的两个预后指标，二者均可通过血液检测轻松且经济高效地进行监测。
