Toth Miklos
Department of Pharmacology, Weill Cornell Medical College, New York, New York.
Genes Brain Behav. 2019 Jan;18(1):e12512. doi: 10.1111/gbb.12512. Epub 2018 Sep 4.
Affiliative social motivation and behavior, that is, sociability that includes attachment, prosocial behavior (sharing, caring and helping) and empathy (the ability to understand and share the feelings of others), has high variability in the human population, with a portion of people outside of the normal range. While psychiatric disorders and autism spectrum disorders are typically associated with a deficit in social behavior, the opposite trait of hypersociability and indiscriminate friendliness are exhibited by individual with specific neurodevelopmental disorders and following early adverse care. Here we discuss both genetic and environmental factors that cause or increase the risk for developing pathological hypersociability from human to rodent models.
亲和性社会动机与行为，即包括依恋、亲社会行为（分享、关心和帮助）以及同理心（理解和分享他人感受的能力）在内的社交性，在人类群体中具有高度变异性，一部分人处于正常范围之外。虽然精神疾病和自闭症谱系障碍通常与社交行为缺陷有关，但具有特定神经发育障碍的个体以及经历早期不良照料后会表现出过度社交和不加区分的友善等相反特征。在这里，我们讨论从人类到啮齿动物模型中导致或增加病理性过度社交风险的遗传和环境因素。
