Cai Jianfei, Zhang Yinjia, Zou Jun, Shen Yan, Luo Dan, Bao Huafang, Chen Yong, Ye Jingfen, Guan Jian-Long
Department of Rheumatology and Immunology, Huadong Hospital affiliated with Fudan University, Shanghai, China.
Department of Diagnostic Ultrasound, Huadong Hospital affiliated with Fudan University, Shanghai, China.
J Clin Lab Anal. 2019 Jan;33(1):e22637. doi: 10.1002/jcla.22637. Epub 2018 Aug 12.
This study aimed to investigate the correlation of serum uric acid (SUA) with risk and dilatation diameter of ascending aortic dilatation (AAD) in Behçet's disease (BD) patients.
Seventeen BD patients complicated with AAD and 20 BD patients without AAD were consecutively enrolled and categorized into AAD group and control group, respectively. Ascending aortic dilatation was determined by two-dimensional doppler echocardiographic examination, and AAD was defined as a diameter of ascending aorta ≥3.8 and <4.4 cm. SUA was detected by quantitative immunoassay method.
Ascending aortic dilatation patients presented with higher proportion of male patients (P = 0.003), hypertension occurrence (P = 0.036) and increased diameter of ascending aorta (P < 0.001) compared to controls. SUA was elevated in AAD patients compared to controls (P = 0.002), and receiver operating characteristic curve displayed that SUA presented with great predictive value for AAD risk in BD patients with area under curve (AUC) 0.821 (95% CI 0.675-0.966). Pearson's analysis also disclosed that SUA was positively correlated with ascending aortic diameter in total BD patients. However, no difference of CRP (P = 0.219) or ESR (P = 0.320) between AAD patients and controls was observed, and no correlation of CRP (R = -0.150, P = 0.377) or ESR (R = 0.067, P = 0.692) with ascending aortic diameter in total BD patients was discovered either. Further multivariate logistic regression illuminated that SUA was an independent factor predicting AAD risk in BD patients (P = 0.031).
Serum uric acid could be served as an independent marker for increased risk and severity of AAD in BD patients.
本研究旨在探讨白塞病（BD）患者血清尿酸（SUA）与升主动脉扩张（AAD）风险及扩张直径的相关性。
连续纳入17例合并AAD的BD患者和20例未合并AAD的BD患者，分别分为AAD组和对照组。通过二维多普勒超声心动图检查确定升主动脉扩张情况，AAD定义为升主动脉直径≥3.8 cm且<4.4 cm。采用定量免疫分析法检测SUA。
与对照组相比，升主动脉扩张患者中男性患者比例更高（P = 0.003）、高血压发生率更高（P = 0.036）且升主动脉直径更大（P < 0.001）。与对照组相比，AAD患者的SUA升高（P = 0.002），受试者工作特征曲线显示，SUA对BD患者AAD风险具有较高的预测价值，曲线下面积（AUC）为0.821（95% CI 0.675 - 0.966）。Pearson分析还显示，在所有BD患者中，SUA与升主动脉直径呈正相关。然而，未观察到AAD患者与对照组之间CRP（P = 0.219）或ESR（P = 0.320）存在差异，在所有BD患者中也未发现CRP（R = -0.150，P = 0.377）或ESR（R = 0.067，P = 0.692）与升主动脉直径存在相关性。进一步的多因素logistic回归分析表明，SUA是BD患者AAD风险的独立预测因素（P = 0.031）。
血清尿酸可作为BD患者AAD风险增加及病情严重程度的独立标志物。
