Department of Cardiology, The First Affiliated Hospital of Xinjiang Medical University, Xinjiang Medical University, Urumqi, China.
Environment Research Institute, Shandong University, Qingdao 266237, China.
Int J Biol Sci. 2023 Jul 31;19(12):3869-3891. doi: 10.7150/ijbs.85467. eCollection 2023.
Aortic aneurysm and dissection (AAD) are a group of insidious and lethal cardiovascular diseases that characterized by seriously threatening the life and health of people, but lack effective nonsurgical interventions. Alterations in metabolites are increasingly recognized as universal features of AAD because metabolic abnormalities have been identified not only in arterial tissue but also in blood and vascular cells from both patients and animal models with this disease. Over the past few decades, studies have further supported this notion by linking AAD to various types of metabolites such as those derived from gut microbiota or involved in TCA cycle or lipid metabolism. Many of these altered metabolites may contribute to the pathogenesis of AAD. This review aims to illustrate the close association between body metabolism and the occurrence and development of AAD, as well as summarize the significance of metabolites correlated with the pathological process of AAD. This provides valuable insight for developing new therapeutic agents for AAD. Therefore, we present a brief overview of metabolism in AAD biology, including signaling pathways involved in these processes and current clinical studies targeting AAD metabolisms. It is necessary to understand the metabolic mechanisms underlying AAD to provides significant knowledge for AAD diagnosis and new therapeutics for treatment.
主动脉瘤和夹层（AAD）是一组隐匿且致命的心血管疾病，严重威胁着人们的生命和健康，但缺乏有效的非手术干预措施。代谢物的改变越来越被认为是 AAD 的普遍特征，因为代谢异常不仅在动脉组织中被发现，而且在来自患有这种疾病的患者和动物模型的血液和血管细胞中也被发现。在过去的几十年中，研究通过将 AAD 与各种类型的代谢物（如源自肠道微生物群或参与 TCA 循环或脂质代谢的代谢物）联系起来，进一步支持了这一观点。这些改变的代谢物中的许多可能有助于 AAD 的发病机制。这篇综述旨在说明机体代谢与 AAD 的发生和发展之间的密切关系，并总结与 AAD 病理过程相关的代谢物的意义。这为开发治疗 AAD 的新治疗剂提供了有价值的见解。因此，我们简要概述了 AAD 生物学中的代谢，包括涉及这些过程的信号通路以及针对 AAD 代谢的当前临床研究。了解 AAD 背后的代谢机制对于 AAD 的诊断和治疗提供了重要的知识。
