Manaker S, Eichen A, Winokur A, Rhodes C H, Rainbow T C
Neurology. 1986 May;36(5):641-6. doi: 10.1212/wnl.36.5.641.
We used quantitative autoradiography to localize thyrotropin releasing hormone (TRH) receptors in human brain. Highest concentrations of TRH receptors were localized within the cortical, basal, and lateral nuclei of the amygdala and the molecular layer of the hippocampus. Low levels were found in the cortex, diencephalon, and basal ganglia. The radioligand bound with similar affinity and pharmacology to pituitary gland as to brain. These data suggest that authentic TRH receptors in the hippocampus and amygdala may mediate the putative effects of TRH on the human brain.
我们使用定量放射自显影技术在人脑中定位促甲状腺激素释放激素（TRH）受体。TRH受体的最高浓度位于杏仁核的皮质核、基底核和外侧核以及海马体的分子层。在皮质、间脑和基底神经节中发现含量较低。放射性配体与垂体和大脑结合的亲和力和药理学特性相似。这些数据表明，海马体和杏仁核中的真正TRH受体可能介导TRH对人脑的假定作用。
