Bright-See E, McKeown-Eyssen G, Jacobson E A, Newmark H W, Mathews R, Morson L, Jazmaji V, Bruce W R
Nutr Cancer. 1985;7(4):211-20. doi: 10.1080/01635588509513857.
Dietary fiber is one of several variables being considered in the study of the relationship between diet and cancer. Intervention trials in which dietary fiber is increased are the most direct way of assessing the possible role of fiber in this disease. Two dietary snack products have been developed for use in a fiber intervention study: the high-fiber snack (HFS), which supplies 23 g of dietary fiber per day (mostly from wheat bran) and the low-fiber product (LFS), which provides 3.5 g. Over a 12-week period, 28 volunteers consumed the HFS for 6 weeks and the LFS for 6 weeks. Compliance, as assessed by reports, through recovery of a riboflavin marker in the urine and fecal fiber analysis, was good. The only adverse effects reported were mild abdominal discomfort and gas. Serum ferritin and calcium decreased in some subjects, indicating a need to supplement the products with these essential minerals. Consumption of the snacks did not affect total energy intake or the intake of the nutrients monitored.
膳食纤维是饮食与癌症关系研究中所考虑的几个变量之一。增加膳食纤维的干预试验是评估纤维在这种疾病中可能作用的最直接方法。已开发出两种用于纤维干预研究的膳食零食产品：高纤维零食（HFS），每天提供23克膳食纤维（主要来自麦麸），以及低纤维产品（LFS），提供3.5克。在12周的时间里，28名志愿者食用HFS 6周，食用LFS 6周。通过报告、尿液中核黄素标记物的回收以及粪便纤维分析评估，依从性良好。报告的唯一不良反应是轻度腹部不适和气体。一些受试者的血清铁蛋白和钙水平下降，表明需要在产品中补充这些必需矿物质。食用这些零食不影响总能量摄入或所监测营养素的摄入量。
