Işıkay Sedat, Işıkay Nurgül, Per Hüseyin, Çarman Kürşat Bora, Kocamaz Halil
Department of Physiotherapy and Rehabilitation, Hasan Kalyoncu University, School of Health Sciences, Gaziantep, Turkey.
Department of Anesthesiology, Şehitkamil Goverment Hospital, Gaziantep, Turkey.
Turk J Pediatr. 2018;60(1):70-75. doi: 10.24953/turkjped.2018.01.010.
Işıkay S, Işıkay N, Per H, Çarman KB, Kocamaz H. Restless leg syndrome in children with celiac disease. Turk J Pediatr 2018; 60: 70-75. Celiac disease (CD) is an immune-mediated enteropathy triggered by ingestion of dietary gluten in genetically predisposed individuals. The aim of the study was to determine the prevalence of restless leg syndrome (RLS) in children with CD and to investigate the associated factors for RLS. Totally 494 children with the ages ranging between 11-18 years were included. Among those, 226 were under follow-up with CD and constituted the study group while other 268 children did not have any symptoms or signs associated with CD and established the control group. The demographic data, educational status and routine laboratory data of children including complete blood count, ferritin, vitamin B12, foliate and 25 (OH) vitamin D levels were recorded. The RLS prevalence and associated symptoms of children were defined with a questionnaire. There was no statistically significant difference between the 2 groups regarding the age and gender. Moreover, RLS prevalence was also similar in both groups (3.5% vs 3.0% in CD and control groups, respectively, p=0.98). However, interestingly, in CD group, the mean age of the patients at the onset of RLS symptoms was statistically significantly younger (p=0.02) and the disease was more severe (p=0.026) than the control group. In correlation analysis in CD group, the RLS severity significantly negatively correlated with serum ferritin, folic acid or 25 (OH) vitamin D levels in Celiac disease group. In this study we did not determine an increased prevalence of RLS in children with CD. However, in CD group, the age at the onset of RLS symptoms was significantly younger and the disease was more severe in CD group compared with the control cases.
伊什凯伊 S、伊什凯伊 N、佩尔 H、恰曼 KB、科卡马兹 H。乳糜泻患儿的不宁腿综合征。《土耳其儿科学杂志》2018 年；60: 70 - 75。乳糜泻（CD）是一种由遗传易感性个体摄入膳食麸质引发的免疫介导性肠病。该研究的目的是确定 CD 患儿中不宁腿综合征（RLS）的患病率，并调查与 RLS 相关的因素。共纳入 494 名年龄在 11 - 18 岁之间的儿童。其中，226 名接受 CD 随访，构成研究组，而其他 268 名儿童没有任何与 CD 相关的症状或体征，组成对照组。记录了儿童的人口统计学数据、教育状况和常规实验室数据，包括全血细胞计数、铁蛋白、维生素 B12、叶酸和 25（OH）维生素 D 水平。通过问卷确定儿童的 RLS 患病率及相关症状。两组在年龄和性别方面无统计学显著差异。此外，两组的 RLS 患病率也相似（CD 组和对照组分别为 3.5%和 3.0%，p = 0.98）。然而，有趣的是，在 CD 组中，RLS 症状发作时患者的平均年龄在统计学上显著更小（p = 0.02），且病情比对照组更严重（p = 0.026）。在 CD 组的相关性分析中，乳糜泻组的 RLS 严重程度与血清铁蛋白、叶酸或 25（OH）维生素 D 水平显著负相关。在本研究中，我们未确定 CD 患儿中 RLS 的患病率增加。然而，与对照病例相比，CD 组中 RLS 症状发作时的年龄显著更小，且病情更严重。
