Delisle M B, Bouissou H, Saidi A
Pathol Res Pract. 1986 Mar;181(1):85-92. doi: 10.1016/S0344-0338(86)80192-3.
Over the last few decades, a new pathology has appeared, directly related to the modified immune status of the hosts. It presents several distinctive points. The central nervous system is particularly affected. The opportunistic pathogenic agents do not usually injure the brain parenchyma and are not known for their aggressiveness in normal adults (papovavirus). Diagnosis of these different diseases is often difficult, some biological tests being irrelevant because of alterations of the immune system (toxoplasmosis). The lesions may be exclusively located in the brain (tuberculosis, lymphomas) which is not usually affected by these agents. Response to therapy is frequently poor, the clinical course being rapid and fatal. However, therapy may be successful in some cases, justifying the use of somewhat aggressive procedures (biopsy) in order to obtain an accurate diagnosis. It is important to be aware of these data, and an understanding of them may help in managing these already difficult patients. They also make possible some interesting pathogenic hypotheses.
在过去几十年里，出现了一种新的病理学，它与宿主免疫状态的改变直接相关。它有几个显著特点。中枢神经系统尤其受到影响。机会性致病因子通常不会损伤脑实质，在正常成年人中也不以其侵袭性而闻名（乳头多瘤空泡病毒）。对这些不同疾病的诊断往往很困难，由于免疫系统的改变，一些生物学检测并不相关（弓形虫病）。病变可能仅位于大脑（结核病、淋巴瘤），而大脑通常不会受到这些病原体的影响。对治疗的反应通常较差，临床病程迅速且致命。然而，在某些情况下治疗可能会成功，这使得使用一些较为激进的程序（活检）以获得准确诊断成为合理的做法。了解这些数据很重要，对它们的理解可能有助于管理这些本就棘手的患者。它们还使得一些有趣的致病假说成为可能。
