系统性红斑狼疮疫苗接种的建议和障碍。
Recommendations and barriers to vaccination in systemic lupus erythematosus.
机构信息
Translational Autoinflammatory Disease Studies, NIAID, NIH, Bethesda, MD, USA; National Institute of Arthritis and Musculoskeletal and Skin Diseases, Bethesda, MD, USA.
Women Medical College, Pakistan.
出版信息
Autoimmun Rev. 2018 Oct;17(10):990-1001. doi: 10.1016/j.autrev.2018.04.006. Epub 2018 Aug 11.
Abstract
Patients with Systemic Lupus Erythematosus (SLE) pose a unique dilemma pertaining to immunization against common pathogens. SLE patients are usually not immunized with vaccines based on the fear of either precipitating infection in this immunosuppressed patient population (with live vaccines) or aggravating autoimmunity and hence lupus flares (with any vaccines). However, elevated vulnerability to infection makes patients with SLE precisely the population that needs protection from vaccine-preventable diseases. A summary of guidelines from the Centers for Disease Control and Prevention, professional societies, review articles and expert opinions regarding use of individual vaccines applicable to adults with SLE is presented in this review.
摘要
红斑狼疮（SLE）患者在针对常见病原体进行免疫接种方面存在独特的困境。由于担心活疫苗会引发免疫抑制患者感染，或任何疫苗都会加重自身免疫并导致狼疮发作，SLE 患者通常不接种疫苗。然而，SLE 患者极易感染，因此他们正是需要预防疫苗可预防疾病的人群。本文综述了美国疾病控制与预防中心、专业协会、综述文章和专家意见中有关适用于 SLE 成人的各种疫苗使用的指南。
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