Oxford Vaccine Group, Department of Paediatrics, University of Oxford, OX3 7LE, United Kingdom.
J Infect. 2016 Jul 5;72 Suppl:S13-22. doi: 10.1016/j.jinf.2016.04.017. Epub 2016 May 24.
Immunocompromised children have a higher risk of developing infections and associated higher rates of mortality and morbidity. Although this group could benefit the most from vaccine administration, specific considerations regarding immunisations are required. This review is a summary of the vaccines that are relevant to the immunocompromised host, covering both live and non-live vaccines. The burden of disease, safety, immunogenicity/effectiveness and specific recommendations for each vaccine are described as well as specific guidelines from different organisations.
免疫功能低下的儿童发生感染的风险更高，相关死亡率和发病率也更高。尽管这组人群最能从疫苗接种中获益，但针对免疫接种仍需要特殊考虑。本文综述了与免疫功能低下宿主相关的疫苗，包括活疫苗和非活疫苗。本文还描述了每种疫苗的疾病负担、安全性、免疫原性/有效性以及各组织的具体推荐意见和指南。
